Mechanism of glycan change involved in the activation of innate immunity
| Project/Area Number |
26440066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Rikkyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Satoshi 立教大学, 理学部, 教授 (60280575)
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| Research Collaborator |
KASE Sawako 立教大学, 理学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / 糖鎖修飾 / Toll/TLR情報伝達系 |
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| Outline of Final Research Achievements |
The innate immune system is the first line of defense encountered by invading pathogens. We have found that immune challenge leads to change host glycosylation, which involved in full activation of immune response. Our aim in this study was to reveal the mechanism of the host glycan change by immune challenge.
In this study, we found that glucosaminoglycan (GAG) regulates immune activity. GAG suppresses hyper-activation of the Toll pathway in the steady state. Interestingly, pathogen infection reduces the expression of a GAG synthesizing enzyme to enhance immune responses. These results indicate that GAG plays an important role in both suppression of runaway inflammation and enhancement of immune responses.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing2015
Author(s)
Miki Yamamoto-Hino, Hideki Yoshida, Tomomi Ichimuya, Sho Sakamura, Megumi Maeda, Yoshinobu Kimura, Norihiko Sasaki, Kiyoko F. Aoki-Kinoshita, Akiko Kinoshita-Toyoda, Hidenao Toyoda, Ryu Ueda, Shoko Nishihara, Satoshi Goto
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Journal Title
Genes to Cells
Volume: 20
Issue: 6
Pages: 521-542
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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