| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Endocytosis is the process to internalize extracellular materials by clathrin coated vesicles (CCV). After internalization, CCV is transported to lysosome via early and late endosomes. However, how these processes are regulated remains unclear. In the previous work, we generated new fluorescence marker for endocytosis in budding yeast, and screened mutants that display endocytic defects. As a result, we identified many mutants in various endocytic steps. In this study, we categorized these mutants into 4 groups according to their phenotypes, and performed detailed analysis.
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