| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Antimicrobial peptides are considered an essential part of the innate immune response of plants, invertebrates and vertebrates as they provide host defenses and can target a wide range of pathogenic microorganisms, including bacteria, fungi, yeast, parasites and viruses. Antimicrobial peptides are thought to kill bacteria by breaking their cell membranes, although the exact mechanisms are still unclear. In this study, we investigated efficient way to prepare isotopically labelled antimicrobial peptides for NMR studies. By using an isotopically labelled antimicrobial peptide, we obtained structural information for LPS-bound form.
|
