Noninvasive in vivo imaging using GFP and quantum dots for elucidation of cancer metastasis mechanism
| Project/Area Number |
26440075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kita Sayaka 東京大学, 大学院理学系研究科(理学部), 特別研究員 (70343564)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | in vivoイメージング / 非侵襲 / ヒトがん細胞 / マウス / in vivo イメージング / がん細胞 / 乳がん細胞 / ゼノグラフトモデル / バイオチャンバー / GFP / 転移がん細胞 / がん幹細胞 / がん転移 |
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| Outline of Final Research Achievements |
In this study, I succeeded in developing a system for non-invasively imaging the metastasis of cancer cells.
In addition, new knockout transgenic mice for noninvasive in vivo imaging targeted to metastatic cancer cells could be generated. It's transgenic mouse was generated using CRISPR / Cas9. The target gene was a Prkdc gene involved with T cells which are immune cells.
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Report
(5 results)
Research Products
(6 results)
