| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
3D density maps by electron microscopy have important information about biomolecular structures. To make a full use of these maps, we developed a WEB server “Omokage search” to search the global shape similarity of biological macromolecules in databases for 3D density maps and atomic models. The server searches using the distance-based profiles from the 3D points of the maps and models. It also performs 3D superimpositions using the Gaussian mixture model (GMM), for approximating shapes of the maps and the models. The new algorithm “Gaussian-input GMM” was developed for converting into GMMs more robustly and rapidly. We started to develop the methods for multiple subunit fitting and alpha-helix detection.
|
