The role of septin participating in the remodeling of neuronal circuits
Project/Area Number |
26440095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 細胞骨格 / 学習 / 記憶 / 神経 |
Outline of Final Research Achievements |
Cytoskeletal remodeling in response to synaptic inputs is a critical process underlying structural plasticity, as is exemplified by the dependence of late-phase LTP and long-term memory on actin remodeling. Unbiased behavioral screening of several mouse lines that are deficient in or overloaded with a septin subunit or a related protein revealed that mice of one such line consistently underperform spatial learning tasks. The unique line may provide a clue to unknown molecular mechanism of spatial cognition and learning. Proteomic analysis revealed quantitative changes in the glutamate receptor subunits and other proteins in the hippocampus.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance.2015
Author(s)
Ageta-Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, Nishioka T, Kaibuchi K, Hattori S, Miyakawa T, Tanaka K, Huda F, Hirai H, Hashimoto K, Watanabe M, Sakimura K, Kinoshita M.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 10090-10090
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system.2014
Author(s)
Watanabe S, Ageta-Ishihara N, Nagatsu S, Takao K, Komine O, Endo F, Miyakawa T, Misawa H, Takahashi R, Kinoshita M, Yamanaka K.
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Journal Title
Mol Brain
Volume: 7
Issue: 1
Pages: 62-62
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Spatial discrimination defects caused by chronic, systemic loss of a septin subunit is recapitulated by its acute, local depletion in the hippocampal dentate gyrus2016
Author(s)
Ageta-Ishihara N, Yamada T, Suzuki Y, Sawada A, Masuda H, Takao K, Miyakawa T, Hioki H, Okamura M, Bito H, Inokuchi K, Kinoshita M
Organizer
包括脳適応回路シンポジウム
Place of Presentation
同志社大学 室町キャンパス 寒梅館 ハーディーホール(京都市)
Year and Date
2016-03-03
Related Report
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