| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
We found that a non-essential nuclear pore complex protein Nup132 is essential for establishment of kinetochore structure and for attachment of kinetochore and microtubule in the meiotic first division, firstly indicating that the nuclear pore complex participates in the meiotic chromosome segregation. Next, we revealed a specific but dispensable regulation for expressions of nuclear pore complex proteins Nup98 and Nup96. We also found that an inner nuclear membrane protein Lem2 is essential for centromere-specific heterochromatin formation. In addition, we developed a novel fluorescent probe to visualize histone modification.
|
