| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Target of rapamycin (TOR) is a kinase that regulates metabolism, proliferation and growth in response to nutrients, stresses etc. TOR forms two different protein complexes, TORC1 and TORC2. On the contrary to TORC1, little was known about the regulation mechanism of TORC2 in any organisms. Since my colleagues and I already had isolated some candidates of the TORC2 regulators in the fission yeast, Schizosaccharomyces pombe, this research project has focused on the regulation mechanism of TORC2 by the candidates. The results obtained in this project indicate that the candidates mediate different stimuli to TORC2 and regulate TORC2 in the different manners. A part of the results showing that a small GTPase Ryh1 mediates glucose signal to TORC2 was disclosed by publishing a research article. The results highlight stress response mechanism of TORC2 and will facilitate investigation of human TORC2.
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