Nobel signaling mechanisms for insulin-dependent glucose uptake in skeletal muscle
Project/Area Number |
26440103
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Osaka Prefecture University |
Principal Investigator |
Satoh Takaya 大阪府立大学, 理学(系)研究科(研究院), 教授 (20251655)
|
Co-Investigator(Kenkyū-buntansha) |
竹中 延之 大阪府立大学, 理学(系)研究科(研究院), 准教授 (20610504)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | インスリン / 骨格筋 / GTP結合蛋白質 / Rac1 / 糖取り込み / 細胞内シグナル伝達 / GTP結合タンパク質 / 糖尿病 / 低分子量GTPアーゼ / グアニンヌクレオチド交換因子 |
Outline of Final Research Achievements |
Insulin regulates the blood glucose level by inducing glucose uptake in skeletal muscle. In this study, we aimed to reveal the role and regulatory mechanisms of the small GTPase Rac1 in insulin-dependent glucose uptake in skeletal muscle by using mouse models. We identified a novel signaling mechanism whereby the guanine nucleotide exchange factor FLJ00068 activates Rac1 downstream of phosphoinositide 3-kinase and the serine/threonine protein kinase Akt2. Furthermore, we found that the small GTPase RalA regulates glucose uptake downstream of Rac1 in skeletal muscle.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] Insulin‐like growth factor‐1 induces activation and upregulating of via PI3K/Akt/mTOR pathway in muscular hypertrophy model of C2C12 cells.2015
Author(s)
Akiho Kushiya, Shuji Ueda, Yusuke Kirimura, Yoshiki Katoh, Midori Ishimasa, Takaya Satoh, Minoru Yamanoue, Yasuhito Shirai
Organizer
The 2015 ASCB Annual Meeting
Place of Presentation
San Diego Convention Center, San Diego, CA, USA
Year and Date
2015-12-15
Related Report
Int'l Joint Research
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