Project/Area Number |
26440104
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Chuo University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 減数分裂 / 細胞周期 / チェックポイント / DNA複製 / 遺伝子組換え / 酵母 / 体細胞分裂 / 遺伝子発現 / 転写因子 |
Outline of Final Research Achievements |
We have been screening for the possible candidates of the meiotic DNA replication checkpoint linking pre-meiotic DNA replication and recombination. We found that meiotic forkhead transcription factor Mei4 is required for this checkpoint. However, we have not found any new factors of the meiotic DNA replication checkpoint linking pre-meiotic DNA replication and the first meiotic division. We have shown that meiRNA which is a non-coding RNA is required for pre-meiotic S phase in the absence of the pheromone signal. We show that meiRNA regulates the expression of the activator of the transcription factor.
|
Report
(5 results)
Research Products
(13 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.2014
Author(s)
Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.
-
Journal Title
Cell Cycle.
Volume: 13
Issue: 7
Pages: 1115-1131
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Book] 化学と生物2018
Author(s)
山田貴富、村上浩士
Total Pages
10
Publisher
国際文献社、
Related Report