Study of regulatory mechanism for intracellular transport using high efficient genome editing mediated by improved TALEN.
| Project/Area Number |
26440108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Ikeda Kazuho 国立研究開発法人理化学研究所, 生命システム研究センター, 研究員 (20642565)
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| Co-Investigator(Renkei-kenkyūsha) |
Okada Yasushi 国立研究開発法人理化学研究所, 生命システム研究センター, チームリーダー (50272430)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細胞内物質輸送 / ゲノム編集 / TALEN / 黒色素胞 / メラノソーム / キネシン |
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| Outline of Final Research Achievements |
Intracellular transport is essential for numerous cellar functions. Many vesicles and organelles are transported along microtubules bidirectionally by opposing MT motors such as dynein and kinesin. However, regulatory mechanism for bidirectional movement of cargos largely remains unclear. In this study, we investigate tug-of-war theory by reconstructing tug-of-war between opposing MT motors in Xenopus melanophore. We also showed MAP4 mediated transport regulation.
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Report
(4 results)
Research Products
(12 results)
