| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Recently, we got a suggestion that our protein Albatross, that regulates cell-cell adhesion (Inoko et al. JCB2008), also contributes to all centriolar dynamics: centriole duplication, spindle formation and primary cilia formation. In this study, we clarified that the molecular basis of cell cycle progression by Albatross is its binding to (1) key players for centriole duplication and (2) key kinases for spindle formation. Taken together, Albatross is the first protein that integrates centrosomal microtubule dynamics. Thus, Albatross is the bi-player for both cell proliferation and cell differentiation.
Also, we succeeded in naive imaging of the Rootletin fiber which contributes to cell cycle regulation as a centrosome connection.
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