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Functional analysis of a novel PCP regulator

Research Project

Project/Area Number 26440113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionAkita University

Principal Investigator

Ayukawa Tomonori  秋田大学, 医学系研究科, 助教 (80586165)

Co-Investigator(Kenkyū-buntansha) 山崎 正和  秋田大学, 医学(系)研究科(研究院), 准教授 (40373378)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords平面内細胞極性 / PCP / 発生生物学 / 遺伝学
Outline of Final Research Achievements

Most tissues and organs acquire a polarity within the plane of the epithelium, which is orthogonal to the axis of apico-basal polarity. This is called planar cell polarity (PCP). PCP pathway is an evolutionarily conserved mechanism in multicellular organism.
PCP molecules are categorized into two groups by its function. In previous study we have already succeeded to find a novel group of PCP regulators (Jbug group). In this study we try to understand molecular mechanism by which Jbug group regulates the PCP pathway.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (7 results)

  • [Journal Article] Dual roles of O-glucose glycans redundant with monosaccharide O-fucose on Notch in Notch Trafficking.2016

    • Author(s)
      Matsumoto, K., Ayukawa, T., Ishio, A., Sasamura, T., Yamakawa, T. and Matsuno, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 26 Pages: 13743-13752

    • DOI

      10.1074/jbc.m115.710483

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dachsous 依存的な Spiny-legs の非対称局在はショウジョウバエに おける平面内細胞極性の方向を決定する2015

    • Author(s)
      鮎川友紀
    • Journal Title

      Akita J Med

      Volume: 42 Pages: 9-17

    • NAID

      120005624821

    • Related Report
      2015 Research-status Report
  • [Journal Article] O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation2015

    • Author(s)
      Akira Ishio, Takeshi Sasamura, Tomonori Ayukawa, Junpei Kuroda, Hiroyuki O. Ishikawa, Naoki Aoyama, Kenjiroo Matsumoto, Takuma Gushiken, Tetsuya Okajima, Tomoko Yamakawa and Kenji Matsuno2
    • Journal Title

      Jounal of Biochemistry

      Volume: 290 Issue: 1 Pages: 505-519

    • DOI

      10.1074/jbc.m114.616847

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dachsous-Dependent Asymmetric Localization of Spiny-Legs Determines Planar Cell Polarity Orientation in Drosophila.2014

    • Author(s)
      Ayukawa T., Akiyama M., Mummery-Widmer JL., Stoeger T., Sasaki J., Knoblich JA., Senoo H., Sasaki T., Yamazaki M.
    • Journal Title

      Cell Rep.

      Volume: 8 Issue: 2 Pages: 610-621

    • DOI

      10.1016/j.celrep.2014.06.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2017

    • Author(s)
      鮎川友紀
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 平面内細胞極性を司る新規調節機構の解析2016

    • Author(s)
      鮎川友紀
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dachsous依存的なSpiny-legsの非対称局在はショウジョウバエにおける平面内細胞極性の方向を決定する2015

    • Author(s)
      鮎川友紀
    • Organizer
      日本解剖学会第61回東北・北海道連合支部学術集会
    • Place of Presentation
      盛岡観光文化交流センター プラザおでって(盛岡)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Dachsous-dependent asymmetric localization of Spiny-legs is critical for determining planar cell polarityorientation in Drosophila2014

    • Author(s)
      Ayukawa T
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] A molecular mechanism underlying planar cell polarity orientation in Drosophila2014

    • Author(s)
      Ayukawa T
    • Organizer
      International symposium on“Homeostasis through development, life, and diseases.”
    • Place of Presentation
      群馬大学 昭和キャンパス 刀城会館(高崎)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Dachsous-dependent polarization of Spiny-legs is critical for determining planar cell polarity orientation in Drosophila2014

    • Author(s)
      Ayukawa T
    • Organizer
      Japanese Drosophila Research Conference 11 (JDRC11)
    • Place of Presentation
      金沢歌劇座(金沢)
    • Year and Date
      2014-06-04 – 2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Dachsous-dependent polarization of Spiny-legs is critical for determining planar cell polarity orientation in Drosophila2014

    • Author(s)
      Ayukawa T
    • Organizer
      47th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      ウインクあいち(名古屋)
    • Year and Date
      2014-05-27 – 2014-05-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-12-17  

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