Characterizatoin of the signaling network that couples reactivation of neuronal progenitors to the nutritional state
| Project/Area Number |
26440116
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 線虫 / 栄養 / 神経前駆細胞 / 発生遺伝学 / PTCHD / 栄養応答 / 食餌環境 / hedgehog / patched / 自閉症スペクトラム / 神経幹細胞 / microRNA / 活性化 / 静止期 |
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| Outline of Final Research Achievements |
In animals, the nervous system is derived from neural stem and progenitor cells. These cells dynamically shuttle between the activated and quiescent states. During the former state, neural stem and progenitor cells actively divide and differentiate to produce neurons. On the other hand, these cells stay dormant during the latter. Better understanding the mechanism that regulates the balance between these two states is believed to contribute to development of regenerative medicine and elucidation of aging process. Using the nematode worm, C. elegans as an experiment system, this study found that PTCHD, which is proposed to be involved in intellectual disability and autism spectrum disorder, plays an important role in maintaining the quiescent state of neural progenitor cells.
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Report
(5 results)
Research Products
(20 results)
