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Alterations of regional specifications of the jaw elements along the proximal-distal axis in the mammalian evolution

Research Project

Project/Area Number 26440127
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental biology
Research InstitutionNihon University

Principal Investigator

SUZUKI Kunihiro  日本大学, 松戸歯学部, 教授 (30256903)

Co-Investigator(Kenkyū-buntansha) 若松 義雄  東北大学, 医学系研究科, 准教授 (60311560)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords顎 / 単弓類 / 進化 / 異形歯性 / ほ乳類 / 歯式 / ホメオボックス / 耳小骨 / 有袋類 / オポッサム / 顎関節 / 歯の発生 / フェレット / マウス / 歯の分化 / ホメオボックスコード
Outline of Final Research Achievements

During the evolution of mammal from ancestral synapsid, regional specifications of the jaw elements have occurred along the proximal-distal axis. In this study, expression of homeobox genes in the jaw primordium of various animals, with special focus on marsupial opossum, was examined, and the results were correlated to the dental formula. Accordingly, Msx1-BarX1 double-positive domain would give rise to the premolars in basic mammals including opossum, while mouse lower jaw primordium lacked such domain.
During mammalian evolution, the jaw joint was modified and the original joint bones were recruited to the middle ear ossicles. It has also been suggested that, in marsupial, the development of jaw joint and middle ear would recapitulate the evolutionary process. The development of jaw joint and middle ear ossicles in opossum, however, did not show such evolutionary events.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (5 results) Book (1 results)

  • [Journal Article] Immunohistological Study of the Major Salivary Glands in the Gray Short-Tailed Opossums (<i>Monodelphis domestica</i>)2017

    • Author(s)
      Hiroya Gotouda, Ryo Tamamura, Tetsuro Kono, Yukari Ootani, Takeshi Kanno, Takao Kuwada-Kusunose, Kunihiro Suzuki, Toshiro Sakae, Hiroyuki Okada, Ikuo Nasu
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 26 Issue: 1 Pages: 75-80

    • DOI

      10.2485/jhtb.26.75

    • NAID

      130005188395

    • ISSN
      1341-7649, 1880-828X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 有袋類オポッサムにおける酸素運搬タンパク質ヘモグロビンの結晶化およびアミノ酸配列データに基づく立体構造予測2016

    • Author(s)
      桑田(楠瀬)隆生、鈴木久仁博
    • Journal Title

      日大口腔科学

      Volume: 42(2) Pages: 61-66

    • NAID

      40020976705

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Conversion of neural plate explants to pre-placodal ectoderm-like tissue in vitro2016

    • Author(s)
      Shigetani Y, Wakamatsu Y, Tachibana T, Okabe M
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 477 Issue: 4 Pages: 807-813

    • DOI

      10.1016/j.bbrc.2016.06.139

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of carious lesions on undecalcified tooth sections with silver staining method for protein gel electrophoresis2016

    • Author(s)
      Kuwada-Kusunose T, Suzuki K, Fuse M, Matsumoto T, Kusunose A, Niimi N, Tamamura R, Okada H, Sakae T
    • Journal Title

      J. Hard Tissue Biol.

      Volume: 25 Pages: 15-20

    • NAID

      130005119564

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ultrastructure of the Salivary Glands in the Gray Short-tailed Opossum (Monodelphis domestica)2015

    • Author(s)
      Kanno T, Suzuki K, KonoT, Tamamura R, Kuwada-Kusunose T, Sakae T, Okada H
    • Journal Title

      Int J Oral-Med Sci

      Volume: 14 Pages: 61-66

    • NAID

      130005126918

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 有袋類の繁殖戦略と特徴的な発生様式2015

    • Author(s)
      若松義雄,鈴木久仁博
    • Journal Title

      生体の科学

      Volume: 66 Pages: 217-221

    • Related Report
      2015 Research-status Report
  • [Journal Article] Comparative gene expression analyses reveal heterochrony for Sox9 expression in the cranial neural crest during marsupial development.2014

    • Author(s)
      Wakamatsu Y, Nomura T, Osumi N, Suzuki K.
    • Journal Title

      Evolution and Development

      Volume: 16 Issue: 4 Pages: 197-206

    • DOI

      10.1111/ede.12083

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 有袋類オポッサムにおける顎の発生ー出生後の形成過程2017

    • Author(s)
      鈴木久仁博、大谷友加里、桑田-楠瀬隆生、玉村亮、河野哲朗、平山達也、平山友彦、岡田裕之、寒河江登志朗
    • Organizer
      日本解剖学会
    • Place of Presentation
      長崎大学、長崎県、長崎市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] オーストラリア有袋類にみられる「多生歯性」の問題について2016

    • Author(s)
      鈴木久仁博
    • Organizer
      日大口腔科学会
    • Place of Presentation
      日本大学、千葉県、松戸市
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有袋類オポッサムにおける酸素運搬タンパク質ヘモグロビンの結晶化およびアミノ酸配列データに基づく立体構造予測2016

    • Author(s)
      桑田(楠瀬)隆生、鈴木久仁博
    • Organizer
      日大口腔科学会
    • Place of Presentation
      日本大学、千葉県、松戸市
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] ハイイロジネズミオポッサムにおける耳下腺および顎下腺の超微細構造学的検討2015

    • Author(s)
      河野哲朗、鈴木久仁博、玉村 亮、菅野岳志、寒河江登志朗、岡田裕之
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟コンベンションセンター(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Recruitment of Sox9 to the neural border specification program in marsupial cranial neural crest development2015

    • Author(s)
      若松義雄,大隅典子,鈴木久仁博
    • Organizer
      日本発生生物学会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2015-06-02 – 2015-06-05
    • Related Report
      2014 Research-status Report
  • [Book] 生体の科学2015

    • Author(s)
      若松義雄,鈴木久仁博
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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