| Project/Area Number |
26440127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
若松 義雄 東北大学, 医学系研究科, 准教授 (60311560)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 顎 / 単弓類 / 進化 / 異形歯性 / ほ乳類 / 歯式 / ホメオボックス / 耳小骨 / 有袋類 / オポッサム / 顎関節 / 歯の発生 / フェレット / マウス / 歯の分化 / ホメオボックスコード |
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| Outline of Final Research Achievements |
During the evolution of mammal from ancestral synapsid, regional specifications of the jaw elements have occurred along the proximal-distal axis. In this study, expression of homeobox genes in the jaw primordium of various animals, with special focus on marsupial opossum, was examined, and the results were correlated to the dental formula. Accordingly, Msx1-BarX1 double-positive domain would give rise to the premolars in basic mammals including opossum, while mouse lower jaw primordium lacked such domain.
During mammalian evolution, the jaw joint was modified and the original joint bones were recruited to the middle ear ossicles. It has also been suggested that, in marsupial, the development of jaw joint and middle ear would recapitulate the evolutionary process. The development of jaw joint and middle ear ossicles in opossum, however, did not show such evolutionary events.
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