| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Neocortex is developed only in mammals and contributes to the higher order brain functions such as cognition, learning and speaking. During corticogenesis, the newborn neurons migrate one after another from the ventricular zone toward the pial surface and the six-layer structure that billions of neurons are arranged elaboratively. The regulatory mechanisms of this process remain elusive. In this study, we found a novel mechanism of subplate neurons in this regulation. The subplate neurons are among the first born and matured neurons in the cortex. We revealed that the subplate neurons sent glutamate signals to multipolar neurons via synaptic transmission and promoted the morphological change of multipolar neurons into bipolar shape and lead to the faster migration mode called locomotion.
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