| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The possible significance of biotic stress-responsive activation of purine catabolism was examined by focusing on two different groups of physiologically active molecules, reactive oxygen species (ROS) that are generated during the catabolic processes, and the phytohormones jasmonates whose levels were recently shown to be enhanced by the accumulation of allantoin，a major stress-induced purine intermediary metabolite. Reverse-genetic studies using the model plant Arabidopsis thaliana suggested that xanthine dehydrogenase, the first enzyme participating in the purine degradation pathway also known as ROS-generating enzyme, is involved in defense against a board range of microbial pathogens. Such studies also revealed that allantoin can activate jasmonate-mediated defense responses in an abscisic acid-dependent manner through the action of MYC2, a master transcriptional regulator in jasmonate signaling.
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