Roles of transcription factor Runx 3 in ovarian follicle development and ovulation in mice
Project/Area Number |
26440167
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | Okayama University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
FUKAMACHI Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70134450)
|
Research Collaborator |
TAKEUCHI Sakae
SAKUMA Atsuko
TSUCHIYA Yukiko
SAITO Yuka
OGO Yuki
OJIMA Fumiya
HAYASHI Sayo
KAYO Daichi
MAEKAWA Tetsuya
GU TinTin
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 排卵 / 卵巣 / ステロイホルモン / マウス / 成長因子 / 転写因子 / ステロイドホルモン |
Outline of Final Research Achievements |
The present study was aimed at clarifying the roles of transcription factor Runx3 in female mice. Runx3 mRNA was detected in the granulosa cells of ovaries, and in the neural cells in hypothalamic areas involved in regulation of ovulation in female mice. In Runx3 knockout female mice, hypothalamic Kisspeptin mRNA and ovarian cholesterol side-chain cleavage enzyme gene mRNA expressions were decreased. Dysfunction of hypothalamic regulatory mechanism of ovulation in Runx3 knockout female mice was demonstrated. These findings clearly suggest that Runx3 was involved in the regulation of ovarian steroid hormone production and hypothalamic ovulatory function.
|
Report
(4 results)
Research Products
(18 results)
-
-
-
-
-
-
[Presentation] Expression of insulin-like growth factor 1 mRNA in granulosa cells of mouse ovarian follicular cells2015
Author(s)
Hayashi, S., Ojima, F., Aizawa, S., Ogoshi, M., Takeuchi, S., Takahashi, S.
Organizer
第40回日本比較内分泌学会大会
Place of Presentation
広島市
Year and Date
2015-12-12
Related Report
-
[Presentation] Postnatal changes of Runx transcription factor gene expression in mouse ovaries2015
Author(s)
Gu, T., Ojima, F., Aizawa, S., Ogoshi, M., Takeuchi, S., Takahshi, S.
Organizer
第40回日本比較内分泌学会大会
Place of Presentation
広島市
Year and Date
2015-12-12
Related Report
-
-
-
-
-
-
-
-
-
-
-