| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The present study was aimed at clarifying the roles of transcription factor Runx3 in female mice. Runx3 mRNA was detected in the granulosa cells of ovaries, and in the neural cells in hypothalamic areas involved in regulation of ovulation in female mice. In Runx3 knockout female mice, hypothalamic Kisspeptin mRNA and ovarian cholesterol side-chain cleavage enzyme gene mRNA expressions were decreased. Dysfunction of hypothalamic regulatory mechanism of ovulation in Runx3 knockout female mice was demonstrated. These findings clearly suggest that Runx3 was involved in the regulation of ovarian steroid hormone production and hypothalamic ovulatory function.
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