| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To develop a better comprehension of diversity and universality in vertebrate physiological regulations, we focus on amphibian hematopoietic responses against environmental stress in African clawed frog (Xenopus laevis) and Western clawed frog (Xenopus (Silurana) tropicalis). We established an in vivo Xenopus hypoxic model that caused a pulmonary defect. This model should be vital to investigate non-hematopoietic functions of erythropoietin. In the latter model, low-temperature exposure induced pancytopenia. We revealed that one of the causes of thrombocytopenia was due to the reversible cellular adhesion between thrombocytes and the vascular wall cells.
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