| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The female reproductive tract consists of the sites for reproduction and is of significant concern for women’s health and disease, notably tumorigenesis. Despite the importance of this organ system, the molecular and cellular mechanisms that regulate cell proliferation and differentiation of these organs are not yet fully understood. In this analysis, we analyzed tissue-specific roles of estrogen receptors and showed that epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina. We also identified several growth factors, including epidermal growth factors (EGFs) and fibroblast growth factors (Fgfs), are involved in terminal differentiation of vaginal epithelial cells.
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