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Evolutionary study on differences of dopamine regulation systems in the brain between sexes in social Hymenoptera

Research Project

Project/Area Number 26440181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionTamagawa University

Principal Investigator

Sasaki Ken  玉川大学, 農学部, 准教授 (40387353)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsbiogenic amine / bumble bee / dopamine / honey bee / reproduction / 繁殖 / 内分泌 / ホルモン / ドーパミン / 昆虫 / 生体アミン / 社会性昆虫 / 生殖器官 / フェロモン
Outline of Final Research Achievements

To clarify dopamine regulation systems in the brains in eusocial bees, dopamine dynamics and factors affecting the levels in the honey bee and the bumble bee were determined. In the honey bee, dopamine has a role in promotion of reproduction in both workers and males. Factors affecting increase of brain dopamine were a presence of a queen (or queen substances) and tyrosine (a precursor of dopamine) supply in workers, and juvenile hormone and tyrosine supply in males. In the bumble bee, a positive correlation between ovarian development and brain dopamine levels was detected in queenless workers, but not in virgin queens with developed ovaries. Thus, the differences of dopamine regulation systems between sexes were found in the honey bee, and roles of dopamine differ between the castes in both species.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (37 results)

All 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 6 results,  Open Access: 4 results) Presentation (23 results) (of which Int'l Joint Research: 2 results) Remarks (4 results)

  • [Journal Article] Queen contact and among-worker interactions dually suppress worker brain dopamine as a potential regulator of reproduction in an ant.2017

    • Author(s)
      Shimoji, H., Aonuma,H., Miura, T., Tsuji, K., Sasaki, K., Okada, Y.
    • Journal Title

      Behavioral Ecology and Sociobiology

      Volume: 71 Issue: 2 Pages: 35-35

    • DOI

      10.1007/s00265-016-2263-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Honeybee males use highly concentrated nectar as fuel for mating flights2016

    • Author(s)
      M. Hayashi, J. Nakamura, K. Sasaki, K. Harano
    • Journal Title

      Journal of Insect Physiology

      Volume: Vol. 93-94 Pages: 50-55

    • DOI

      10.1016/j.jinsphys.2016.08.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tyraminergic and octopaminergic modulation of defensive behavior in termite soldier2016

    • Author(s)
      Y. Ishikawa, H. Aonuma, K. Sasaki, T. Miura
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 5 Pages: e0154230-e0154230

    • DOI

      10.1371/journal.pone.0154230

    • NAID

      120005981399

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 社会性ハチ類における脳内ドーパミン制御機構の性差2016

    • Author(s)
      佐々木謙
    • Journal Title

      昆虫と自然

      Volume: Vol. 51 Pages: 36-38

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nutrition and dopamine: an intake of tyrosine in royal jelly can affect the brain levels of dopamine in male honeybees (Apis mellifera L.)2016

    • Author(s)
      K. Sasaki
    • Journal Title

      Journal of Insect Physiology

      Volume: 87 Pages: 45-52

    • DOI

      10.1016/j.jinsphys.2016.02.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dopamine regulates termite soldier differentiation through trophallactic behaviors2016

    • Author(s)
      H. Yaguchi, T. Inoue, K. Sasaki, K. Maekawa
    • Journal Title

      Royal Society open science

      Volume: 3 Issue: 2 Pages: 150574-150574

    • DOI

      10.1098/rsos.150574

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlated responses in death-feigning, activity, and biogenic amine of strains selected for walking distance in the red flour beetle, Tribolium castaneum2016

    • Author(s)
      K. Matsumura, K. Sasaki, T. Miyatake
    • Journal Title

      Journal of Ethology

      Volume: 34 Issue: 2 Pages: 97-105

    • DOI

      10.1007/s10164-015-0452-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Octopamine and cooperation: octopamine regulates the disappearance of cooperative behaviours between genetically unrelated founding queens in the ant.2015

    • Author(s)
      Satoshi Koyama, Shingo Matsui, Toshiyuki Satoh and Ken Sasaki
    • Journal Title

      Biology letters

      Volume: 11 Issue: 6 Pages: 1-4

    • DOI

      10.1098/rsbl.2015.0206

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Consumption of tyrosine in royal jelly increases brain levels of dopamine and tyramine and promotes transition from normal to reproductive workers in quenless honey bee colonie2015

    • Author(s)
      Matsuyama S, Nagao T, Sasaki K
    • Journal Title

      General and Comparative Endocrinology

      Volume: 211 Pages: 1-8

    • DOI

      10.1016/j.ygcen.2014.11.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Social dominance and reproductive differentiation mediated by dopaminergic signaling in a queenless ant.2015

    • Author(s)
      Yasukazu Okada, Ken Sasaki, Satoshi Miyazaki, Hiroyuki Shimoji, Kazuki Tsuji and Toru Miura
    • Journal Title

      The Journal of Experimental Biology

      Volume: 218 Issue: 7 Pages: 1091-1098

    • DOI

      10.1242/jeb.118414

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ミツバチ雄の飛翔行動と脳内アミン2017

    • Author(s)
      佐々木謙
    • Organizer
      第6回ミツバチシンポジウム
    • Place of Presentation
      福岡大学(福岡県・福岡市)
    • Year and Date
      2017-02-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Regulation system of brain dopamine for reproduction in social insects2016

    • Author(s)
      K. Sasaki
    • Organizer
      ICE 2016 XXV International Congress of Entomology
    • Place of Presentation
      Orange county convention center, Orland, Florida (アメリカ合衆国)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soldier caste determination through regulation of social communications in termites2016

    • Author(s)
      H. Yaguchi, S. Shigenobu, K. Sasaki, K. Maekawa
    • Organizer
      ICE 2016 XXV International Congress of Entomology
    • Place of Presentation
      Orange county convention center, Orland, Florida (アメリカ合衆国)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene expression of dopamine receptors in the reproductive organ during sexual maturation in honeybee males2016

    • Author(s)
      K. Matsushima, K. Sasaki
    • Organizer
      日本比較生理生化学会第38回大会
    • Place of Presentation
      玉川大学(東京都・町田市)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dopamine in the reproductive organs in honeybee males2016

    • Author(s)
      T. Takahashi, K. Sasaki
    • Organizer
      日本比較生理生化学会第38回大会
    • Place of Presentation
      玉川大学(東京都・町田市)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Octopamine regulates the disappearance of food exchange between genetically unrelated founding queens in the ant2016

    • Author(s)
      K. Sasaki, S. Koyama, T. Satoh
    • Organizer
      日本比較生理生化学会第38回大会
    • Place of Presentation
      玉川大学(東京都・町田市)
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 真社会性の中に組み込まれた単独性種の生理機構2016

    • Author(s)
      佐々木謙
    • Organizer
      日本進化学会第18回大会
    • Place of Presentation
      東京工業大学(東京都・目黒区)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] セイヨウミツバチの栄養摂取による脳内ドーパミン量への影響2016

    • Author(s)
      佐々木謙
    • Organizer
      第60回日本応用動物昆虫学会
    • Place of Presentation
      大阪府立大学(大阪府堺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] セイヨウミツバチ雄の性成熟に伴ったドーパミン合成と受容体遺伝子発現2016

    • Author(s)
      松島啓将・目澤龍介・佐々木謙
    • Organizer
      第60回日本応用動物昆虫学会
    • Place of Presentation
      大阪府立大学(大阪府堺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] フタモンアシナガバチの産卵ワーカーは女王型の個体なのか?2016

    • Author(s)
      土田浩治・浅井一行・渡邊大・杉目康広・三浦徹・佐々木謙・横井翔
    • Organizer
      第60回日本応用動物昆虫学会
    • Place of Presentation
      大阪府立大学(大阪府堺市)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Cooperation regulated by octopamine in ant founding queens2015

    • Author(s)
      S. Koyama, Matsui, S., Satoh, T., Sasaki, K.
    • Organizer
      Comp Biol 2015 (日本比較生理生化学会第37回大会)
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] ミツバチ雄の性成熟に関わる末梢器官でのドーパミンの作用2015

    • Author(s)
      松島啓将・佐々木謙
    • Organizer
      第52回日本昆虫学会関東支部大会
    • Place of Presentation
      玉川大学(東京都町田市)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ミツバチワーカー・雄のチロシン摂取が脳内ドーパミン量へおよぼす影響2015

    • Author(s)
      佐々木謙
    • Organizer
      第34回日本動物行動学会
    • Place of Presentation
      東京海洋大学(東京都港区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] ミツバチ雄の性成熟に伴う脳内ドーパミン合成と末梢器官での受容体発現2015

    • Author(s)
      松島啓将・目澤龍介・佐々木謙
    • Organizer
      第34回日本動物行動学会
    • Place of Presentation
      東京海洋大学(東京都港区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] ミツバチのオスは選択的に高糖度の蜜を補給し飛行に関わるコストを回避する2015

    • Author(s)
      林雅貴・中村純・佐々木謙・原野健一
    • Organizer
      第34回日本動物行動学会
    • Place of Presentation
      東京海洋大学(東京都港区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 分散能力に対する人為選抜が擬死行動、活動性、生体アミン量へ及ぼす影響2015

    • Author(s)
      松村健太郎・佐々木謙・宮竹貴久
    • Organizer
      第34回日本動物行動学会
    • Place of Presentation
      東京海洋大学(東京都港区)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] モンシロチョウ雌における交尾拒否行動の生理・分子メカニズム2015

    • Author(s)
      佐々木謙・巣籠瑛・内山博允・矢嶋俊介
    • Organizer
      第17回日本進化学会
    • Place of Presentation
      中央大学(東京都文京区)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Research-status Report
  • [Presentation] The effect of dopamine on fighting behavior of honey bee virgin queens2015

    • Author(s)
      Farkhary S. I., Sasaki K., Koyama S., Satoh T.
    • Organizer
      日本応用動物昆虫学会第59回大会
    • Place of Presentation
      山形大学(山形)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ミツバチワーカーと雄のチロシン摂取による脳内ドーパミン量への影響2014

    • Author(s)
      佐々木謙
    • Organizer
      日本動物行動学会第33回大会
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] ミツバチ雄の幼若ホルモン類似物質による脳内ドーパミン合成酵素への作用2014

    • Author(s)
      松島啓将, 目澤龍介, 佐々木謙
    • Organizer
      日本動物行動学会第33回大会
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2014-11-01 – 2014-11-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Nutritional regulation of the brain levels of dopamine and tyramine to promote the transition from normal to reproductive workers in queenless colonies of honey bees.2014

    • Author(s)
      Sasaki K., Mastuyama S., Nagao T.
    • Organizer
      11th International Congress of Neuroethology
    • Place of Presentation
      Sapporo Convention Center (Hokkaido, Japan)
    • Year and Date
      2014-07-28 – 2014-08-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Regulation of brain dopamine by nutrition in female honeybees.2014

    • Author(s)
      Sasaki K., S. Matsuyama S., Nagao T.
    • Organizer
      International Congress of IUSSI 2014
    • Place of Presentation
      Cairns convention Centre (Queensland, Australia)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Octopamine regulates social behaviors between genetically unrelated ant queens.2014

    • Author(s)
      Koyama S., Mastui S., Satoh T., Sasaki K.
    • Organizer
      International Congress of IUSSI 2014
    • Place of Presentation
      Cairns Convention Centre (Queensland, Australia)
    • Year and Date
      2014-07-13 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Remarks] ResearchGate Homepage

    • URL

      https://www.researchgate.net/profile/Ken_Sasaki2

    • Related Report
      2016 Annual Research Report
  • [Remarks] ResearchGate Homepage (英文)

    • URL

      https://www.researchgate.net/profile/Ken_Sasaki2

    • Related Report
      2015 Research-status Report
  • [Remarks] Research map (和文・英文)

    • URL

      http://researchmap.jp/read0054468

    • Related Report
      2014 Research-status Report
  • [Remarks] Research Gate (英文)

    • URL

      https://www.researchgate.net/profile/Ken_Sasaki2

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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