Mode of action of thyroid hormone in brain to open the sensitive period for learning

• Project/Area Number: 26440182
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: Teikyo University
• Principal Investigator: Homma Koichi 帝京大学, 薬学部, 教授 (90251438)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経科学 / 脳・神経 / 行動学 / 薬学 / 動物 / 刷り込み / 学習感臨界期 / ニワトリ

Outline of Final Research Achievements

The purpose of this study is to reveal the mode of action of thyroid hormone in brain to open the sensitive period for learning of filial imprinting. We found that acute protein phosphorylation cascade occurred in response to the inflow of thyroid hormone at an early phase of learning. As a result, intracellular cytoskeletal organization and the electrophysiological changes were induced and then the memory information was stored in the novel brain region we identified recently.

Research Products

• [Journal Article] Sex differences in brain thyroid hormone levels during early post-hatching development in zebra finch (Taeniopygia guttata) (2017)
  • Author(s): Yamaguchi S., Hayase S., Aoki N., Takehara A., Ishigohoka J., Matsushima T., Wada K., Homma K.J.
  • Journal Title: PLoS One Volume: 12 Issue: 1 Pages: 1-15
  • DOI: 10.1371/journal.pone.0169643
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of nucleotide diphosphate kinase 2 in the reopening of the sensitive period of filial imprinting of domestic chicks (Gallus gallus domesticus) (2016)
  • Author(s): Yamaguchi S, Aoki N, Takehara A, Mori M, Kanai A, Matsushima T, Homma KJ.
  • Journal Title: Neurosci Letter Volume: 612 Pages: 32
  • DOI: 10.1016/j.neulet.2015.12.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Critical role of the neural pathway from the intermediate medial mesopallium to the intermediate hyperpallium apicale in filial imprinting of domestic chicks (Gallus gallus domesticus) (2015)
  • Author(s): Aoki N, Yamaguchi S, Kitajima T, Takehara A, Katagiri-Nakagawa S, Matsui R, Watanabe D, Matsushima T, Homma KJ.
  • Journal Title: Neuroscience. Volume: 308 Pages: 115
  • DOI: 10.1016/j.neuroscience.2015.09.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum (2014)
  • Author(s): Yamaguchi, S., Aoki, N., Kitajima, T., Okamura, Y. and Homma, K. J.
  • Journal Title: Communicative & Integrative Biology Volume: 7 Issue: 5 Pages: 1-4
  • DOI: 10.4161/19420889.2014.970502
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potential role of voltage-sensing phosphatases in regulation of cell structure through the production of PI(3,4)P₂ (2013)
  • Author(s): Yamaguchi S, Kurokawa T, Taira I, Aoki N, Sakata S, Okamura Y & Homma KJ
  • Journal Title: J. Cell Physiol. Volume: 229 Issue: 4 Pages: 422
  • DOI: 10.1002/jcp.24463
  • Peer Reviewed / Open Access
• [Presentation] GABA-A受容体とGABA-B受容体の機能的な役割の転換が鳥類刻印付けの学習臨界期 を決定する (2016)
  • Author(s): 青木 直哉 、山口 真二、佐伯 百合子、武原 顕彦、松島 俊也、本間 光一
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-07-20
• [Presentation] ニワトリヒナにおいて甲状腺ホルモンは学習経験依存の学習促進効果をもたらす (2016)
  • Author(s): 武原顕彦、青木直哉、山口真二、本間光一
  • Organizer: 日本動物学会第６８回関東支部大会
  • Place of Presentation: 神奈川大学横浜キャンパス
  • Year and Date: 2016-03-12
• [Presentation] Critical role of the novel neural pathway in the cerebrium in filial imprinting of newly-hatched domestic chicks (2016)
  • Author(s): 山口真二、青木直哉、本間光一
  • Organizer: Integrative Network Linking Multiple Brain Areas for Behavioral Adaptation
  • Place of Presentation: 同志社大学 寒梅館
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] 甲状腺ホルモンの非遺伝子的作用による学習能力の賦与 (2016)
  • Author(s): 本間 光一
  • Organizer: 創剤フォーラム第２２回シンポジウム
  • Place of Presentation: 帝京大学薬学部
  • Invited
• [Presentation] 鳥類刻印付けにおけて大脳背側部IMHAは獲得・想起に必要である (2015)
  • Author(s): 青木直哉、山口真二、北島孝明、本間光一
  • Organizer: 第67回日本動物学会関東支部大会
  • Place of Presentation: 早稲田大学先端生命医科学センター
  • Year and Date: 2015-03-14
• [Presentation] 甲状腺ホルモンは、刷り込み学習の感受性期の開始を決定し、その後の学習のプライマーとして働く (2014)
  • Author(s): 山口真二、青木直哉、松島俊也、本間光一
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 鳥類刻印付けの成立に大脳後背側部IMHAは必須である (2014)
  • Author(s): 青木直哉、山口真二、北島孝明、松島俊也、本間光一
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Thyroid hormone confers 'memory priming' to start the sensitive period of imprinting in birds. (2014)
  • Author(s): 本間光一
  • Organizer: 2014 International Congress of Neuroethology,Hokkaido
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2014-07-28 – 2014-08-01
  • Invited
• [Presentation] Hormonal regulation of the sensitive period for filial imprinting in domestic chicks. (2014)
  • Author(s): 山口真二、青木直哉、本間光一
  • Organizer: 2014 International Congress of Neuroethology,Hokkaido Neuroethology workshops
  • Place of Presentation: 北海道大学理学部生命科学科
  • Year and Date: 2014-07-26 – 2014-07-27
• [Presentation] Neural circuits of the sensitive period triggered by thyroid hormones in filial imprinting. (2014)
  • Author(s): 青木直哉、山口真二、本間光一
  • Organizer: 2014 International Congress of Neuroethology,Hokkaido Neuroethology workshops
  • Place of Presentation: 北海道大学理学部生命科学科
  • Year and Date: 2014-07-26 – 2014-07-27
• [Remarks] 帝京大学薬学部ホームページ
  • URL: http://www.pharm.teikyo-u.ac.jp/
• [Remarks] 帝京大学教員情報
  • URL: https://www.e-campus.gr.jp/staffinfo/public/staff/detail/450/16