| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Synchronous oscillatory activity in a laminar structure is common in the central nervous system of both vertebrates and invertebrates. In the terrestrial slugs, periodic oscillation is recorded from the surface of the laminar structure of procerebrum (PC), olfactory center, and its frequency changes are suggested to encode the olfactory information and memory. We found that in vitro oscillatory neuronal network was formed from dispersed cell culture of PC neurons. Nicotine or acetylcholine esterase inhibitor induced synchronous oscillatory activity in the culture networks. Previous our studies show acetylcholine increased frequency of LFP oscillation in the PC may be via nicotinic ACh receptors. These results suggest cholinergic system can function as a major chemical transmitter in cultured PC neuron network. It may play an essential role, such as driving force for synchronous oscillation in the olfactory neuron network.
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