| Project/Area Number |
26440188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
|
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
Inoue Yoshihiro 京都工芸繊維大学, 応用生物学系, 准教授 (90201938)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
山口 政光 京都工芸繊維大学, 応用生物学系, 教授 (00182460)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ショウジョウバエ / ミトコンドリア / 細胞周期 / ダイナミクス / 減数分裂 / ミトコンドリア動態 / 細部周期 |
|---|
| Outline of Final Research Achievements |
Mitochondria are dynamic organelles that engage in repeated cycles of fusion and fission. It serves to intermix the contents among mitochondria and to maintain a quality of a mitochondria population in a cell. In this study, we showed that the meiotic entry of a primary spermatocyte is inhibited when sever damages in mitochondrial DNA occurred. Activation of CDK1 failed to be observed in the arrested cells. The nuclear to cytoplasm transport of cyclin B was perturbed in the cells. We revealed that there is a checkpoint mechanism that monitors a condition of mitochondria and arrests the meiotic cell cycle in the presence of their abnormalities, such as mitochondrial DNA damage. To avoid production of abnormal sperm, such a specific checkpoint mechanism has been possibly provided in germline cells but not in somatic cells in Drosophila.
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