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Variations in the medaka craniofacial morphology : searching for the responsible genes

Research Project

Project/Area Number 26440191
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Genetics/Chromosome dynamics
Research InstitutionKeio University

Principal Investigator

SHINYA Minori  慶應義塾大学, 商学部(日吉), 准教授 (00372946)

Co-Investigator(Renkei-kenkyūsha) NARUSE Kiyoshi  基礎生物学研究所, バイオリソース研究室, 特任教授 (50208089)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords量的形質 / QTL / 頭蓋顔面形態 / メダカ / 統計遺伝学的解析 / 遺伝学的解析
Outline of Final Research Achievements

Craniofacial morphology is a complex but interesting trait with high variety within a species while maintaining the particular morphology of the species. Logical questions have been posed in order to address variations in cranial morphology, such as how these traits are inherited, which genes regulate the diversity, and how differences between individuals within a species are generated during developmental or life processes. To answer these questions, we had performed quantitative trait loci (QTL) analyses using medaka. QTL analysis suggested the relationships between L33 and chromosome (chr) 6, D29 and chr 15, D29 and chr 22, and V13 and chr 5. Narrowing analysis using congenic strains revealed that about 5 Mbp region of chr 6 affects to L33. On the other hand, D29 were failed to be confirmed the relationships with both chr 15 and 22. V13 was turned out to be too unstable to analyze further.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015 2014

All Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Genetic analysis of quantitative traits: craniofacial morphology2016

    • Author(s)
      Minori Shinya, Tetsuaki Kimura, Kiyoshi Naruse
    • Organizer
      Joint Meeting of the 22nd International Congress of Zoology & The 87th Meeting of the Zoological Society of Japan
    • Place of Presentation
      Okinawa Convention Center, Ginowan City, Okinawa
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 種内多様性を有する頭蓋顔面形態の遺伝学的解析2015

    • Author(s)
      新屋みのり、木村哲晃、成瀬清
    • Organizer
      日本動物学会第86回大会
    • Place of Presentation
      新潟コンベンションセンター(新潟市・新潟県)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Genetic analysis of quantitative traits: craniofacial morphology2014

    • Author(s)
      Minori Shinya, Tetsuaki Kimura, Kiyoshi Naruse
    • Organizer
      20th Japanese Medaka and Zebrafish Meeting
    • Place of Presentation
      Keio University Shiba-Kyoritsu Campus (Minato-ku, Tokyo)
    • Year and Date
      2014-09-20 – 2014-09-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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