Epigenetic inheritance caused by paternal restraint stress in Drosophila

• Project/Area Number: 26440192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Seong Ki-Hyeon 国立研究開発法人理化学研究所, 石井分子遺伝学研究室, 協力研究員 (40425632)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 拘束ストレス / ショウジョウバエ / エピジェネティクス / エピジェネティク遺伝 / dATF-2 / エピジェネティック遺伝 / 非メンデル遺伝

Outline of Final Research Achievements

At present, the experimental evidences of epigenetic inheritance caused by stresses are beginning to accumulate in some animal models. However, molecular mechanism and biological meaning underlying these phenomena has not been clearly understood yet. We have established a new experimental system for analyzing epigenetic effects of drosophila exposed to restraint stress (RS). We observed that Drosophila F1 progenies, derived from RS exposed fathers, showed significant disruption of heterochromatin state and reduced energy metabolic rate. We also found that p38-dATF-2 pathway might play a central role for the epigenetic inheritance induced by RS.

Research Products

• [Journal Article] The plant homeodomain finger protein MESR4 is essential for embryonic development in Drosophila (2015)
  • Author(s): Seong KH, Tsuda M, Tsuda-Sakurai K, Aigaki T.
  • Journal Title: Genesis Volume: 53 Issue: 11 Pages: 701-708
  • DOI: 10.1002/dvg.22906
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a novel role for Drosophila MESR4 in lipid metabolism (2015)
  • Author(s): Tsuda-Sakurai K, Seong KH, Horiuchi J, Aigaki T, Tsuda M.

  • Journal Title: Genes to Cells Volume: 20 Issue: 4 Pages: 358-365
  • DOI: 10.1111/gtc.12221
  • Peer Reviewed / Open Access
• [Journal Article] 環境要因によるエピゲノム変化と記憶 (2015)
  • Author(s): 成耆鉉、石井俊輔
  • Journal Title: 細胞工学 Volume: 34 Pages: 879-883
• [Presentation] ショウジョウバエ父親への拘束ストレス依存的エピジェネティック遺伝現象の解析 (2016)
  • Author(s): 成耆鉉、石井俊輔
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 日本大学国際関係学部 三島駅北口校舎（静岡県三島市）
  • Year and Date: 2016-09-07
  • Invited
• [Presentation] Epigenetic inheritance caused by paternal restraint stress in Drosophila. (2015)
  • Author(s): Seong KH, Ishii S.
  • Organizer: 24th European Drosophila Research Conference
  • Place of Presentation: Heidelberg Germany
  • Year and Date: 2015-09-09
  • Int'l Joint Research
• [Presentation] Epigenetic change and its inheritance caused by paternal restraint stress in Drosophila (2015)
  • Author(s): Seong, KH, Ishii, S
  • Organizer: Waddington Symposium Epigenetics in dialogue with THE GENOME
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2015-06-01
  • Int'l Joint Research