Integration process of microRNAs into gene regulatory network and its evolution.

• Project/Area Number: 26440197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Evolutionary biology
• Research Institution: Kagawa University
• Principal Investigator: Iwama Hisakazu 香川大学, 総合生命科学研究センター, 准教授 (20398035)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: マイクロRNA / 哺乳類 / ターゲット遺伝子 / 遺伝子制御網

Outline of Final Research Achievements

Based on publicly available by-organ human transcriptome data sets and exhaustive microRNA (miRNA) target prediction, the present study quantitatively demonstrates that the miRNA targeting characteristic of mutually exclusive expression between miRNAs and target genes is formed by mammalian evolution. This study also revealed quantitatively that human miRNAs prefer targeting genes with intermediate levels of expression and that the preference has been formed by mammalian evolution.

Research Products

• [Journal Article] Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution (2018)
  • Author(s): Iwama Hisakazu、Kato Kiyohito、Imachi Hitomi、Murao Koji、Masaki Tsutomu
  • Journal Title: PLOS ONE Volume: 13 Issue: 5 Pages: 198142-198142
  • DOI: 10.1371/journal.pone.0198142
  • Peer Reviewed / Open Access
• [Presentation] ヒト・マイクロRNAとターゲットの発現強度の相関とマイクロRNAの古さ (2016)
  • Author(s): 岩間久和、 藤田浩二、井町仁美、村尾孝児、正木 勉
  • Organizer: 日本遺伝学会第88回大会
  • Place of Presentation: 静岡
  • Year and Date: 2016-09-08
• [Presentation] ヒト・マイクロRNAの臓器別発現量とターゲット選択特性 (2015)
  • Author(s): 岩間久和、藤田浩二、井町仁美、村尾孝児、正木 勉
  • Organizer: 日本遺伝学会第87回大会
  • Place of Presentation: 宮城
  • Year and Date: 2015-09-25
• [Presentation] マイクロRNAの生起時期と臓器別発現量 (2015)
  • Author(s): 岩間久和、藤田浩二、井町仁美、村尾孝児、正木 勉
  • Organizer: 日本進化学会第17回大会
  • Place of Presentation: 東京
  • Year and Date: 2015-08-20
• [Presentation] ヒト・マイクロRNAの生起時期と発現量およびターゲット機能 (2014)
  • Author(s): 岩間久和、藤田浩二、井町仁美、村尾孝児、正木 勉
  • Organizer: 日本遺伝学会第86回大会
  • Place of Presentation: 滋賀
  • Year and Date: 2014-09-17
• [Presentation] ヒト・マイクロRNAの生起時期と発現量及びターゲット機能 (2014)
  • Author(s): 岩間久和、藤田浩二、井町仁美、村尾孝児、正木 勉
  • Organizer: 日本進化学会第１6回大会
  • Place of Presentation: 大阪
  • Year and Date: 2014-08-22