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Prediction of human migration by H. pylori and and evolutionary analysis of the virulence

Research Project

Project/Area Number 26440198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Evolutionary biology
Research InstitutionOita University

Principal Investigator

Suzuki Rumiko  大分大学, 医学部, 助教 (70599092)

Co-Investigator(Kenkyū-buntansha) 山岡 吉生  大分大学, 医学部, 教授 (00544248)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsHelicobacter pylori / 人類移動 / 病原性 / 系統解析 / 集団解析 / ピロリ菌 / ゲノムシーケンス / 胃がん / 胃MALTリンパ腫 / 胃炎 / 次世代シーケンサー / 胃ガン / ゲノム
Outline of Final Research Achievements

This study focused on two subjects: (1) prediction of prehistoric human migration in Asia using H. pylori, and (2) exploration of new virulence factors in H. pylori. As for the subject (1), we found that there are unique H. pylori strains in Okinawa and that divergence date of Okinawa specific strains is estimated as 20,000 to 30,000 B.C. This result suggests that human population might have reached to Ryukyu islands before Jomon era. As for the subject (2), we compared genomic sequences of H. pylori isolated from gastric cancer and MALT lymphoma patients. As the results, we found loci where amino acid frequency differs significantly between the two disease groups in major virulence genes cagA and vacA.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Differences in amino acid frequency in CagA and VacA sequences of <i>Helicobacter pylori</i> distinguish gastric cancer from gastric MALT lymphoma.2016

    • Author(s)
      Hashinaga M, Suzuki R, Akada J, Matsumoto T, Kido Y, Okimoto T, Kodama M, Murakami K, Yamaoka Y
    • Journal Title

      Gut Pathog.

      Volume: 8:54 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s13099-016-0137-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Helicobacter pyloriから探る人類の旅2016

    • Author(s)
      鈴木留美子・山岡吉生
    • Journal Title

      Helicobacter Research

      Volume: vol.20 no.5 Pages: 45-59

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Rare Helicobacter pylori Virulence Genotypes in Bhutan2016

    • Author(s)
      Matsunari O, Miftahussurur M, Shiota S, Suzuki R, Vilaichone RK, Uchida T, Ratanachu-Ek T, Tshering L, Mahachai V, Yamaoka Y.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep22584

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence2015

    • Author(s)
      Trang TT, Shiota S, Matsuda M, Binh TT, Suzuki R, Vilaichone RK, Mahachai V, Tshering L, Dung HD, Uchida T, Matsunari O, Myint T, Khien VV, Yamaoka Y.
    • Journal Title

      Biomed Res Int.

      Volume: 830813 Pages: 1-8

    • DOI

      10.1155/2015/830813

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Epidemiology of Helicobacter pylori Infection in Nepal: Specific Ancestor Root2015

    • Author(s)
      Miftahussurur M, Sharma RP, Shrestha PK, Suzuki R, Uchida T, Yamaoka Y.
    • Journal Title

      PLoS One

      Volume: 10(7) Issue: 7 Pages: 1-16

    • DOI

      10.1371/journal.pone.0134216

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Search for novel candidate mutations for metronidazole resistance in Helicobacter pylori using next-generation sequencing2014

    • Author(s)
      Binh TT, Suzuki R, Trang TT, Kwon DH, Yamaoka Y
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 59 Issue: 4 Pages: 2343-2348

    • DOI

      10.1128/aac.04852-14

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] コロンブス後の南米におけるピロリ菌・mtDNA・ Y2016

    • Author(s)
      鈴木留美子, 小野孝明, 塩田星児, 山岡吉生
    • Organizer
      日本進化学会第18回大会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都目黒区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Helicobacter pyloriから推定する先史アジアの人類移動2015

    • Author(s)
      鈴木留美子, 斎藤成也,佐藤万仁,平野隆, 山岡吉生
    • Organizer
      日本進化学会
    • Place of Presentation
      中央大学後楽園キャンパス(東京都、文京区)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Geographic diversity of Helicobacter pylori genomes and predicted host human migration2015

    • Author(s)
      Rumiko Suzuki, Binh Tran Thanh, Muhammad Miftahussurur, Subsomwong Phawinee, Osamu Matsunari, Yoshio Yamaoka
    • Organizer
      日本ヘリコバクター学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県、神戸市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] ピロリ菌から推定する先史時代アジアの人類2014

    • Author(s)
      鈴木留美子
    • Organizer
      日本進化学会
    • Place of Presentation
      高槻現代劇場(大阪府高槻市)
    • Year and Date
      2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] ピロリ菌から推定するアジアの人類移動2014

    • Author(s)
      鈴木留美子
    • Organizer
      第20回日本ヘリコバクター学会学術集会
    • Place of Presentation
      東京ステーションカンファレンス(東京都千代田区)
    • Year and Date
      2014-06-29
    • Related Report
      2014 Research-status Report
  • [Remarks] 大分大学医学部環境・予防医学講座ホームページ

    • URL

      http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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