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Theoretical and empirical studies for compensatory molecular evolution

Research Project

Project/Area Number 26440202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Evolutionary biology
Research InstitutionHokkaido University (2015-2016)
National Institute of Genetics (2014)

Principal Investigator

Osada Naoki  北海道大学, 情報科学研究科, 准教授 (70416270)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords分子進化 / 集団遺伝 / 相互作用 / 共進化 / 有害変異
Outline of Final Research Achievements

Compensatory molecular evolution refers to the process where the fixation of multiple mutation that are singly deleterious maintain organismal fitness by compensating their effects. In this research project, we mainly focus on the compensatory weak selection model, where the fixation of slightly advantageous mutations follow the fixation of slightly deleterious mutations in a variety of molecular systems, including protein-protein interaction and gene expression.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (6 results)

  • [Journal Article] Translational repression of a splice variant of cynomolgus macaque CXCL1L by its C-terminal sequence2017

    • Author(s)
      Hisayuki Nomiyama, Naoki Osada, Ichiro Takahashi, Keiji Terao, Kazuya Yamagata, Osamu Yoshie
    • Journal Title

      J. Interferon Cytokine Res.

      Volume: 37 Issue: 3 Pages: 129-138

    • DOI

      10.1089/jir.2016.0085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compensatory Evolution2016

    • Author(s)
      Naoki Osada
    • Journal Title

      Encyclopedia of Evolutionary Biology

      Volume: 1 Pages: 329-333

    • DOI

      10.1016/b978-0-12-800049-6.00174-8

    • ISBN
      9780128004265
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Population genetics of non-genetic traits: evolutionary roles of stochasticity in gene expression2015

    • Author(s)
      Katsuhiko Mineta, Tomotaka Matsumoto, Naoki Osada, Hitoshi Araki
    • Journal Title

      Gene

      Volume: 562 Issue: 1 Pages: 16-21

    • DOI

      10.1016/j.gene.2015.03.011

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ecological genomics in Xanthomonas: the nature of genetic adaptation with homologous recombination and host shifts2015

    • Author(s)
      Chao-Li Huang, Pei-Hua Pu, Hao-Jen Huang, Huang-Mo Sung, Hung-Jiun Liaw, Yi-Min Chen, Chien-Ming Chen, Ming-Ban Huang, Naoki Osada, Takashi Gojobori, Tun-Wen Pai, Yu-Tin Chen*, Chi-Chuan Hwang*, Tzen-Yuh Chiang
    • Journal Title

      BMC Genomics

      Volume: 16 Issue: 1 Pages: 188-188

    • DOI

      10.1186/s12864-015-1369-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic diversity in humans and non-human primates and its evolutionary consequences2015

    • Author(s)
      Naoki Osada
    • Journal Title

      Genes & Genetic Systems

      Volume: 90 Issue: 3 Pages: 133-145

    • DOI

      10.1266/ggs.90.133

    • NAID

      130005105460

    • ISSN
      1341-7568, 1880-5779
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Complex patterns of cis-regulatory polymorphisms in ebony underlie standing pigmentation variation in Drosophila melanogaster2015

    • Author(s)
      Ryutaro Miyagi, Noriyoshi Akiyama, Naoki Osada, Aya Takahashi
    • Journal Title

      Mol. Ecol.

      Volume: 24 Issue: 23 Pages: 5829-5841

    • DOI

      10.1111/mec.13432

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] An individual-based diploid model predicts limited conditions under which stochastic gene expression becomes advantageous2015

    • Author(s)
      Tomotaka Matsumoto, Katsuhiko Mineta, Naoki Osada, Hitoshi Araki
    • Journal Title

      Frontiers in Genetics

      Volume: 6 Pages: 336-336

    • DOI

      10.3389/fgene.2015.00336

    • NAID

      120005981380

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Compensatory Evolution2015

    • Author(s)
      Naoki Osada
    • Journal Title

      Encyclopedia of Evolutionary Biology

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] キイロショウジョウバエ自然集団由来のアリルサンプルを用いたトランスクリプトーム解析2016

    • Author(s)
      長田直樹,宮城竜太郎,高橋文
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係各部三島駅北口校舎
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] アリル特異的遺伝子発現の定量によるキイロショウジョウバエ(Drosophila melanogaster)の逆交雑における遺伝子発現変化の原因究明2016

    • Author(s)
      高田恭彰,高橋文,宮城竜太郎,遠藤俊徳,長田直樹
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係各部三島駅北口校舎
    • Year and Date
      2016-09-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Revisiting the relationship between evolutionary conservation and disease causality: a case study of beta globin gene2016

    • Author(s)
      Sageetha Ratnayake, Toshinori Endo, Naoki Osada
    • Organizer
      日本遺伝学会第88回大会
    • Place of Presentation
      日本大学国際関係各部三島駅北口校舎
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] モーリシャス島産カニクイザルの24個体の全ゲノム配列の解析2016

    • Author(s)
      櫻井聡一,遠藤俊徳,長田直樹
    • Organizer
      日本進化学会第18回大会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 旧世界ザルにおけるサルレトロウィルスの内在化に関する進化系統解析2016

    • Author(s)
      池田昌輝,遠藤俊徳,長田直樹
    • Organizer
      第32回日本霊長類学会大会
    • Place of Presentation
      鹿児島大学
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] モーリシャス島産カニクイザルの全ゲノムシークエンス解析2015

    • Author(s)
      長田直樹,Hettiarachchi Nilmini, Babarinde Isaac Adeyemi,斎藤成也,Blancher Antoine
    • Organizer
      第31回日本霊長類学会大会
    • Place of Presentation
      京都大学吉田キャンパス
    • Year and Date
      2015-07-19
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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