Mechanism and biological significance of glucose inactivation of transporters in yeast
| Project/Area Number |
26450084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
GOMI Katsuya 東北大学, 大学院農学研究科, 教授 (60302197)
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| Research Collaborator |
FUJITA Shoki
TAKEKOSHI Yutaro
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 酵母 / モノカルボン酸輸送体 / グルコース不活性化 / エンドサイトーシス / 輸送体 / デグロン / 出芽酵母 / 膜輸送体 / 発現制御 / リボソーム / グルコース抑制 |
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| Outline of Final Research Achievements |
Yeast is a microbe that contributes to bread making and alcohol fermentation. Incorporation of lactic acid and pyruvate by yeast is inhibited in a medium containing glucose. This phenomenon is partly due to glucose-induced endocytic degradation, so-called as glucose inactivation, of Jen1. It is known that glucose inactivation of Jen1 is triggered by its ubiquitination by Rsp5-Rod1 ubiquitin ligase complex. We discovered that the C-terminal 20-amino-acid region of Jen1 recognized by Rsp5-Rod1 complex and sufficient to induce glucose inactivation of transmembrane transporter.
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Report
(5 results)
Research Products
(13 results)
