Type IV pilus machinery of Thermus thermophilus
Project/Area Number |
26450102
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied microbiology
|
Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
|
Research Collaborator |
Koike Ayumi (Takeshita Ayumi)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 線毛 / 高度好熱菌 / Thermus thermophilus / ATPase / リポタンパク質 |
Outline of Final Research Achievements |
The extreme thermophile Thermus thermophilus produces Type IV pili (T4P) on the cell surface. A gene deletion of a protein found in T4P machinery led to loss of twitching motility and sensitivity to a T4P-dependent phage. The expression of the genes encodeing the structural protein of HB8 in HB27 was not sufficient for twitching motility and infection of T4P-dependent phage. This result suggests that T4P-related function requires other protein(s) in addition to the structural proteins.
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Report
(4 results)
Research Products
(10 results)