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Huge number of secondary metabolism genes in fungal genomes: roles and regulation by environmental signal transduction pathways

Research Project

Project/Area Number 26450109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied microbiology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Motoyama Takayuki  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (70291094)

Co-Investigator(Kenkyū-buntansha) 廣田 洋  国立研究開発法人理化学研究所, 理研-KRIBB連携研究ユニット, 客員研究員 (00126153)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsイネいもち病菌 / 糸状菌ゲノム / 二次代謝 / 抗生物質 / シグナル伝達 / 応用微生物 / 菌類 / ゲノム
Outline of Final Research Achievements

We found that TAS1, the tenuazonic acid biosynthetic gene of the rice blast fungus, codes for a new-type secondary metabolite biosynthetic enzyme, and involved in infection. We also found that environmental signals induce tenuazonic acid production via an epigenetic regulator and a transcription factor. Furthermore, we isolated a tenuazonic acid production-inducing compound from a chemical library. This compound induced production of secondary metabolites in other fungus, suggesting that there is a common mechanism in secondary metabolite production control.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Structure-activity relationships of terpendole E and its natural derivatives.2017

    • Author(s)
      Nagumo Y, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H, Usui T
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 4 Pages: 1533-1536

    • DOI

      10.1002/slct.201602015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism.2016

    • Author(s)
      Motoyama T, Osada H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Issue: 24 Pages: 5843-5850

    • DOI

      10.1016/j.bmcl.2016.11.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme2015

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama & Hiroyuki Osada
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8758-8758

    • DOI

      10.1038/ncomms9758

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi2014

    • Author(s)
      Maeda, K., Nakajima, Y., Motoyama, T., Kitou, Y., Kosaki, T., Saito, T., Nishiuchi, T., Kanamaru, K., Osada, H., Kobayashi, T., Kimura, M.
    • Journal Title

      Letters in Applied Microbiology

      Volume: 59 Issue: 4 Pages: 377-383

    • DOI

      10.1111/lam.12289

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive mode ESI-MS2014

    • Author(s)
      Hongo Y., Nakamura T., Takahashi S., Motoyama T., Hayashi T., Hirota H., Osada H., Koshino H.
    • Journal Title

      J. Mass Spectrom.

      Volume: 49 Issue: 6 Pages: 537-542

    • DOI

      10.1002/jms.3360

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導条件の探索と大量生産株の作製2017

    • Author(s)
      本山高幸、田中陽子、長田裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] イネいもち病菌におけるかび毒テヌアゾン酸の生産制御機構2017

    • Author(s)
      尹忠銖、本山高幸、長田裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] イネいもち病菌におけるピリクロール類生合成に関わるFAD依存性モノオキシゲナーゼ遺伝子の解析2017

    • Author(s)
      古山祐貴、本山高幸、鎌倉高志、野川俊彦、長田裕之
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都市
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Activation of fungal secondary metabolism by disturbance of the two-component signal transduction system and identification of the nectriapyrone biosynthetic gene cluster2016

    • Author(s)
      Takayuki Motoyama, Yoko Tanaka, Hiroyuki Osada
    • Organizer
      9th Joint Natural Products Conference 2016
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biosynthesis of mycotoxin tenuazonic acid by novel type of fungal PKS/NRPS hybrid enzyme2016

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      9th Joint Natural Products Conference 2016
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2016-07-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] イネいもち病菌のピリクロール類生合成遺伝子クラスターの同定2016

    • Author(s)
      古山祐貴、本山高幸、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市白石区)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] カビ由来新規 NRPS-PKS 融合酵素によるカビ毒テヌアゾン酸の生合成2016

    • Author(s)
      尹 忠銖、本山 高幸、長田 裕之
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市白石区)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] イネいもち病菌におけるカビ毒テヌアゾン酸の生合成2016

    • Author(s)
      尹 忠銖、本山 高幸、長田 裕之
    • Organizer
      第59回日本放線菌学会学術講演会
    • Place of Presentation
      東京電機大学 東京千住キャンパス 1 号館 1 階 100 周年ホール(東京都足立区)
    • Year and Date
      2016-03-07
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 糸状菌二次代謝を標的とした農薬探索2015

    • Author(s)
      本山 高幸、尹 忠銖、長田 裕之
    • Organizer
      BMB2015ワークショップ「新農薬を志向したケミカルバイオロジー」
    • Place of Presentation
      神戸商工会議所(兵庫県神戸市中央区)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 新たなNRPS-PKS融合酵素によるかび毒テヌアゾン酸の生合成2015

    • Author(s)
      尹忠銖、本山高幸、長田裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス
    • Place of Presentation
      ルミエール府中 (東京都府中市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] ハイグロマイシンB処理によるルシラクタエン生産糸状菌Fusarium sp. RK97-94における二次代謝産物生産誘導2015

    • Author(s)
      加藤 翔、本山 高幸、鎌倉 高志、長田 裕之
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学(岡山県岡山市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 糸状菌の生合成制御による有用生理活性物質生産2014

    • Author(s)
      本山 高幸、植木 雅志、加藤 翔、鎌倉 高志、長田 裕之
    • Organizer
      2014年度 生物生産工学研究センターシンポジウム「生合成マシナリーの精密解析と有用物質生産への応用」
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-12-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ハイグロマイシンB処理によるルシラクタエン生産糸状菌Fusarium sp. RK97-94における二次代謝産物生産誘導2014

    • Author(s)
      加藤 翔、本山 高幸、鎌倉 高志、長田 裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 化合物アレイを用いたメラニン生合成阻害剤探索2014

    • Author(s)
      本山 高幸、田中 陽子、長田 裕之
    • Organizer
      第14回糸状菌分子生物学コンファレンス
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Bioactivity of tenuazonic acid and its production control mechanism in Magnaporthe oryzae2014

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd RIKEN-SNU symposium
    • Place of Presentation
      RIKEN, Wako, Saitama, Japan
    • Year and Date
      2014-04-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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