| Project/Area Number |
26450119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HIROTA Keiko 筑波大学, 生命環境系, 助教 (00375370)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKO Koichiro 筑波大学, 生命環境系, 講師 (60311594)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 線虫 / 寿命 / メチオニン代謝 / 食餌 / メチオニン回路 / 栄養 |
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| Outline of Final Research Achievements |
Many lines of evidence suggest that various restricted dietary regimens, such as caloric restriction and short-term starvation (STS), extend individual lifespans. However, the mechanisms by which STS extends lifespan remain unclear. This study determined that STS, at the beginning of life, increased longevity by prolonging healthy conditions. However, methionine supplementation under STS conditions partially eliminated the increase in longevity, suggesting the partial need for a temporal reduction in methionine to facilitate STS-induced increases in lifespan. To investigate the molecular mechanisms underlying STS-induced longevity, we explored the effects of STS at the metabolite level in the methionine cycle, which implied that the metabolite changes in the methionine cycle were involved in STS-induced longevity.
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