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MRI analysis of olfactory neurocircuits that discriminate odor and pheromone signals

Research Project

Project/Area Number 26450129
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied biochemistry
Research InstitutionKumamoto University

Principal Investigator

Yoshinaga Sosuke  熊本大学, 大学院生命科学研究部(薬), 講師 (00448515)

Co-Investigator(Renkei-kenkyūsha) TERASAWA Hiroaki  熊本大学, 大学院生命科学研究部(薬), 教授 (10300956)
TOUHARA Kazushige  東京大学, 大学院農学生命科学研究科, 教授 (00280925)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords匂い / フェロモン / 脳・神経 / MRI / 嗅覚 / 嗅球 / MRI / 副嗅球
Outline of Final Research Achievements

Olfaction is one of the most important perceptions for animals to receive information from their environments, such as in case of species preservation and danger avoidance. The information is transmitted through odor and pheromone substances, resulting in emotional, behavioral or physiological changes.
Here, we successfully observed odor responses that were evoked by odor and pheromone-like substances in the mouse whole brain, using functional MRI methods. Our developed analytical procedure efficiently identified mouse brain regions in which MR signal changes were synchronized with the periodic odor stimulations. Unique brain regions were activated by each odor and pheromone-like substance.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (18 results) (of which Int'l Joint Research: 11 results)

  • [Journal Article] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 3844-3844

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 5363-5363

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an awake mouse MRI method using soft immobilization for a cryogenic probe system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 1757-1757

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An iterative reconstruction method for dual-band EPI in small-animal studies.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 3242-3242

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Image-based phase correction for dual-band EPI with slice-GRAPPA using point-by-point procedures in k-space.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 4315-4315

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MEMRI and BOLD analyses of the olfactory perception system in response to odorant stimuli in mice.2015

    • Author(s)
      Funatsu, H., Yoshinaga, S., Goto, H., Hirakane, M., Iwamoto, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 23 Pages: 2033-2033

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pre-scan with half-sized phase encoding blips reducing ghost and slice leakage artifacts in dual-band EPI.2015

    • Author(s)
      Toyoda, H., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 23 Pages: 2406-2406

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel reconstruction method for multi-band EPI in animal scanners with iterative point-by-point procedures in k-space.2015

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Magn. Reson. Mat. Phys. Biol. Med.

      Volume: 28

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2017-04-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 独立成分解析を利用したマウス嗅覚受容システムの BOLD 解析2017

    • Author(s)
      舩津大嗣、林芙優、吉永壮佐、杠直哉、草薙俊輔、武田光広、寺沢宏明
    • Organizer
      ISMRM日本支部第1回学術集会
    • Place of Presentation
      脳情報通信融合研究センター、大阪
    • Year and Date
      2017-02-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optimization of the awake mouse MRI method using mouse clothes for a cryogenic coil system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detecting the olfactory responses in the mouse whole brain using a cryogenic probe.2016

    • Author(s)
      Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2016-09-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] fMRI analyses of the mouse olfactory perception system using a cryogenic probe.2016

    • Author(s)
      Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      The XXVIIth ICMRBS (International Conference on Magnetic Resonance in Biological Systems)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of an awake mouse MRI method using soft immobilization for a cryogenic probe system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Image-based phase correction for dual-band EPI with slice-GRAPPA using point-by-point procedures in k-space.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An iterative reconstruction method for dual-band EPI in small-animal studies.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BOLD法を用いた匂い刺激によるマウス脳活性化の検出2015

    • Author(s)
      舩津大嗣、吉永壮佐、平金真、岩本成人、寺沢宏明
    • Organizer
      第54回NMR討論会
    • Place of Presentation
      千葉工業大学津田沼キャンパス、千葉
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
  • [Presentation] A novel reconstruction method for multi-band EPI in animal scanners with iterative point-by-point procedures in k-space.2015

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      ESMRMB (European Society for Magnetic Resonance in Medicine and Biology) 2015 32nd annual scientific meeting
    • Place of Presentation
      Edinburgh International Conference Centre (EICC), Edinburgh, U.K.
    • Year and Date
      2015-10-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 極低温プローブに適用可能なマウス服を用いたawake MRI測定法の開発2015

    • Author(s)
      草薙俊輔、木村一成、平金真、岩本成人、荒木力太、吉永壮佐、寺沢宏明
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル、東京
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] BOLD 法を用いた匂い刺激によるマウス嗅球の活性化の検出2015

    • Author(s)
      舩津大嗣、吉永壮佐、平金真、岩本成人、寺沢宏明
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル、東京
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of an awake mouse MR imaging method using soft immobilization for a cryogenic probe system.2015

    • Author(s)
      Kusanagi, S., Kimura, K., Funatsu, H., Hirakane, M., Iwamoto, S., Araki, R., Yoshinaga, S., and Terasawa, H.
    • Organizer
      WMIC (World Molecular Imaging Congress) 2015
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-09-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A robust Nyquist ghost suppression for high-resolution echo planar imaging of small animal brains.2015

    • Author(s)
      Toyoda, H., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Organizer
      OHBM (Organization for Human Brain Mapping) annual conference 2015
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2015-06-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] MEMRI and BOLD analyses of the olfactory perception system in response to odorant stimuli in mice.2015

    • Author(s)
      Funatsu, H., Yoshinaga, S., Goto, H., Hirakane, M., Iwamoto, S., and Terasawa, H.
    • Organizer
      23rd ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Year and Date
      2015-06-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pre-scan with half-sized phase encoding blips reducing ghost and slice leakage artifacts in dual-band EPI.2015

    • Author(s)
      Toyoda, H., Yuzuriha, N., Yoshinaga, S., and Terasawa, H.
    • Organizer
      23rd ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Metro Toronto Convention Centre, Toronto, Canada
    • Year and Date
      2015-06-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRIを用いた匂い物質の識別メカニズムの解析2014

    • Author(s)
      後藤はるな、平金真、吉永壮佐、舩津大嗣、岩本成人、寺沢宏明
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      ホテルグランヴィア京都(京都市)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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