| Project/Area Number |
26450132
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied biochemistry
|
|---|
| Research Institution | Japan Women's University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TSUGE Hideaki 京都産業大学, 総合生命科学部, 教授 (40299342)
|
|---|
| Research Collaborator |
YOSHIDA Toru 京都産業大学, 総合生命科学部, 研究助教 (30724546)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | DyP / DyP型ペルオキシダーゼ / 分子進化 / 収束進化 / タンパク質工学 / 立体構造のトポロジー / タンパク質機能 / ＤｙＰ型ペルオキシダーゼ |
|---|
| Outline of Final Research Achievements |
DyP-type peroxidase is a novel peroxidase family, which was defined in 2007. Therefore, we had little known its physiological function and structure. In this study, we tried to solve the relationship between its structure and function. Interestingly, DyP-type peroxidase family has been found to be devided to 3 classes, that is classes P, I and V based on strucutral based homology alignment. Moreover, each class must be evolved independently from different origin. It suggests that some of proteins as well as DyP-type peroxidase family also do convergent evolution as some organisms.
|
