| Project/Area Number |
26450146
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
WADA Akimori 神戸薬科大学, 薬学部, 教授 (80158683)
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| Co-Investigator(Renkei-kenkyūsha) |
SHICHIDA Yoshinori 京都大学, 大学院・理学研究科, 教授 (60127090)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | チャネルロドプシン / 発色団 / 長い共役系 / 赤色光 / レチナール / ケミカルバイオロジー / 共役系 / 長波長吸収 / オプトジェネティクス / チャンネルロドプシン |
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| Outline of Final Research Achievements |
Optogenetics is a powerful new tool, which allows control of neuronal activity by light. Channelrhodopsins are light-gated cation channels and have been used for optogenetics. In order to construct a new type of channelrhodopsin having the chromophore responding to the longer wavelength, we prepared the novel retinal analogs with double bond-elongated at the Schiff base, side chain or cyclohexene ring of retinal and 3,4-dehyrdoretinal.All analogs synthesized here bound to apo-protein to afford the new channelrhodopsins. Although the red shift values of ramuda max were only 10-20 nm, these channelrhodopsins exhibited the half of absorption maximum at about 560-580 nm, which were about 50-80 nm red shifted than that of native channelrhodopsin.
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