| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Enhanced indoleamine 2, 3-dioxygenase (IDO) or decreased amino carboxymuconate semialdehyde decarboxylase (ACMSD) expression leads to increased levels of toxic metabolite quinolinic acid. In this study, we investigated the regulatory mechanism of tryptophan metabolic key enzymes by food ingredients. We found energy restricted diet increased ACMSD activity, and rat ACMSD was regulated by the transcription factor HNF4 alpha and other transcription factors.
Moreover, we examined the effect of ferulic acid (FA) in microglial cells on IDO expression levels and its mechanism. FA suppressed LPS-induced IDO mRNA expression and also suppressed nuclear translocation of NF-κB and phosphorylation of p38 MAPK in microglial cells. Our results indicate that FA decreases LPS-induced IDO expression, which may be mediated by suppression of the NF-κB and p38 MAPK pathways.
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