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Development of the vaccine for food allergy using degradated allergens

Research Project

Project/Area Number 26450151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Yoshida Tadashi  東京農工大学, (連合)農学研究科(研究院), 准教授 (20302911)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアレルギー / 免疫寛容 / ワクチン / 分解アレルゲン
Outline of Final Research Achievements

The aim of this study is to demonstrate the efficacy and safety of the vaccine for food allergy using degradated allergens.
We first prepared the degradated allergen by treating the allergen under the acid condition. We then evaluated the antigenicity and T cell stimulatory activity of the degradated allergen, and showed that the treatment could be used to prepare the degradated allergen having T cell stimulatory activity with reduced antigenicity. We finally showed that the oral administration of the degradated allergen to food allergy model mice inhibited the induction of food allergy triggered by the subsequent intake of the intact allergen. Our results demonstrated that the efficacy and safety of the food allergy vaccine.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] 分解アレルゲンを用いた食品アレルギー予防ワクチンの開発へ向けて2016

    • Author(s)
      好田正,尾近和信,古田早紀,大竹愛,服部誠
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 54-57

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 経口免疫寛容により誘導されたアナジー化T細胞の網羅的DNAメチル化解析2017

    • Author(s)
      豊田彩乃,古崎利紀,石井一夫,服部誠,好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都府京都市、京都女子大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] 酸分解抗原を用いた食品アレルギーの予防2016

    • Author(s)
      尾近和信,服部誠, 後藤真生,石川祐子,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京都文京区、東京大学
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of the changes of expression and DNA methylation status of anergy related genes induced by anergy induction2016

    • Author(s)
      豊田彩乃,服部誠,好田正
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄県宜野湾市、沖縄コンベンションセンター
    • Related Report
      2016 Annual Research Report
  • [Presentation] 経皮感作による食品アレルギーの増悪化への影響2015

    • Author(s)
      不破有沙、服部誠、好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京大学伊藤謝恩ホール(文京区)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
  • [Presentation] アレルギーを誘導することなく経口免疫寛容を誘導しうる食品抗原の簡便な調製法の検討2015

    • Author(s)
      古田早紀、服部誠、後藤真生、石川(高野)祐子、好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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