Development of the vaccine for food allergy using degradated allergens

• Project/Area Number: 26450151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Yoshida Tadashi 東京農工大学, (連合)農学研究科(研究院), 准教授 (20302911)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アレルギー / 免疫寛容 / ワクチン / 分解アレルゲン

Outline of Final Research Achievements

The aim of this study is to demonstrate the efficacy and safety of the vaccine for food allergy using degradated allergens.
We first prepared the degradated allergen by treating the allergen under the acid condition. We then evaluated the antigenicity and T cell stimulatory activity of the degradated allergen, and showed that the treatment could be used to prepare the degradated allergen having T cell stimulatory activity with reduced antigenicity. We finally showed that the oral administration of the degradated allergen to food allergy model mice inhibited the induction of food allergy triggered by the subsequent intake of the intact allergen. Our results demonstrated that the efficacy and safety of the food allergy vaccine.

Research Products

• [Journal Article] 分解アレルゲンを用いた食品アレルギー予防ワクチンの開発へ向けて (2016)
  • Author(s): 好田正，尾近和信，古田早紀，大竹愛，服部誠
  • Journal Title: アレルギーの臨床 Volume: 36 Pages: 54-57
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 経口免疫寛容により誘導されたアナジー化T細胞の網羅的DNAメチル化解析 (2017)
  • Author(s): 豊田彩乃，古崎利紀，石井一夫，服部誠，好田正
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都府京都市、京都女子大学
• [Presentation] 酸分解抗原を用いた食品アレルギーの予防 (2016)
  • Author(s): 尾近和信，服部誠, 後藤真生，石川祐子，好田正
  • Organizer: 日本食品免疫学会
  • Place of Presentation: 東京都文京区、東京大学
  • Year and Date: 2016-11-09
• [Presentation] Analysis of the changes of expression and DNA methylation status of anergy related genes induced by anergy induction (2016)
  • Author(s): 豊田彩乃，服部誠，好田正
  • Organizer: 日本免疫学会
  • Place of Presentation: 沖縄県宜野湾市、沖縄コンベンションセンター
• [Presentation] 経皮感作による食品アレルギーの増悪化への影響 (2015)
  • Author(s): 不破有沙、服部誠、好田正
  • Organizer: 日本食品免疫学会
  • Place of Presentation: 東京大学伊藤謝恩ホール（文京区）
  • Year and Date: 2015-10-15
• [Presentation] アレルギーを誘導することなく経口免疫寛容を誘導しうる食品抗原の簡便な調製法の検討 (2015)
  • Author(s): 古田早紀、服部誠、後藤真生、石川（高野）祐子、好田正
  • Organizer: 日本農芸化学会
  • Place of Presentation: 岡山
  • Year and Date: 2015-03-28