Identification of RAGE inhibitory components in foods and elucidation of its inhibitory mechanism
| Project/Area Number |
26450152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 博 金沢大学, その他部局等, その他 (00115198)
山本 靖彦 金沢大学, 医学系, 教授 (20313637)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | RAGE / food function / 食品 / 機能成分 / 機能性成分 |
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| Outline of Final Research Achievements |
Receptor for advanced glycation end products (RAGE) is a pattern recognition receptor, which has been implicated in the pathogenesis of diabetic complications, inflammation, Alzheimer's disease, and cancer. Therefore it is important for RAGE relation diseases to inhibit RAGE signaling. In this study, we isolated and identified RAGE signaling inhibitory components derived from Japanese soy sauce low molecular fraction. Furthermore cos7 cells were transfected with a plasmid containing full length RAGE cDNA and V1, C1, C2 domain-deleted RAGE cDNAs to clear the essential domain for RAGE multimerization.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer2017
Author(s)
Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination.2015
Author(s)
Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.
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Journal Title
Gastric Cancer
Volume: 18
Issue: 4
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism2014
Author(s)
Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J.
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Journal Title
Allergology International
Volume: 63
Issue: 1
Pages: 57-66
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury.2014
Author(s)
Sakai S, Tajima H, Miyashita T, Nakanuma SI, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S, Fujimura T, Saito H, Munesue S, Yamamoto Y, Ohta T.
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Journal Title
Dig Dis Sci
Volume: 59(4)
Issue: 4
Pages: 787-794
DOI
Related Report
Peer Reviewed / Open Access
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