| Project/Area Number |
26450152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山本 博 金沢大学, その他部局等, その他 (00115198)
山本 靖彦 金沢大学, 医学系, 教授 (20313637)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | RAGE / food function / 食品 / 機能成分 / 機能性成分 |
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| Outline of Final Research Achievements |
Receptor for advanced glycation end products (RAGE) is a pattern recognition receptor, which has been implicated in the pathogenesis of diabetic complications, inflammation, Alzheimer's disease, and cancer. Therefore it is important for RAGE relation diseases to inhibit RAGE signaling. In this study, we isolated and identified RAGE signaling inhibitory components derived from Japanese soy sauce low molecular fraction. Furthermore cos7 cells were transfected with a plasmid containing full length RAGE cDNA and V1, C1, C2 domain-deleted RAGE cDNAs to clear the essential domain for RAGE multimerization.
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