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Molecular design of novel phenylpropanoid-derived anti-amyloidal compounds using quantum-dot probes

Research Project

Project/Area Number 26450153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionShinshu University

Principal Investigator

NAKAMURA Soichiro  信州大学, 役員等, 理事 (00105305)

Co-Investigator(Renkei-kenkyūsha) TOKURAKU Kiyotaka  室蘭工業大学, 工学系研究科, 准教授 (00332106)
HIGUCHI Keiichi  信州大学, 学術研究院医学系, 教授 (20173156)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords量子ドットプローブ / フェニルプロパノイド / 脂肪酸エステル / 抗アミロイド性新素材 / 生体系における効果 / アミロイド性タンパク質 / ユニバーサル量子ドットプローブ / SK-N-SH細胞 / マウス初代培養ニューロン / Aβ過剰発現ショウジョウバエ / 線虫Cenorhabditis elegans / 安息香酸エステル / ユニバーサルプローブ / 抗アミロイド効果 / アミロイドーシス発症モデルハエ / グリコ・リポフィル化フェルラ酸
Outline of Final Research Achievements

With the progress of super aging society, diseases caused by deposition of amyloid fibrils are becoming a social problem. In this study, I focused on phenylpropanoids that are widely distributed in nature, and tried to create novel active compounds linked with sugar chains or fatty acid chains of different chain length and hydrophobicity. And then, structure-function relationship was investigated to enhance their anti-amyloidal activities. For measurement of anti-amyloidal activity, amyloidgenic peptide-linked quantum dots was used as a probe. In addition, experiments using drosophila and nematode were also conducted. As a result, ferulic acid ester and caffeic acid ester synthesized by lipase were proposed as a novel anti-amyloidal compound.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results) Presentation (17 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus2017

    • Author(s)
      N Lebetwa, T Mitani, S Nakamura, S Katayama
    • Journal Title

      Journal of the Science of Food and Agriculture

      Volume: 97 Issue: 6 Pages: 1939-1944

    • DOI

      10.1002/jsfa.7999

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities2017

    • Author(s)
      Heng, M.Y., Katayama, S., Mitani, T., Ong, E.S., Nakamura, S.
    • Journal Title

      Food Chem.

      Volume: 221 Pages: 1388-1393

    • DOI

      10.1016/j.foodchem.2016.11.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 82016

    • Author(s)
      Katayama, S., Sugiyama, H., Kushimoto, S., Uchiyama, Y., Hirano, M., Nakamura, S
    • Journal Title

      J. Agric. Food Chem.

      Volume: 64 Issue: 24 Pages: 4008-4013

    • DOI

      10.1021/acs.jafc.6b01237

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biophysical characterization of the domain association between cytosolic A and B domains of the mannitol transporter enzymes IIMtl in the presence and absence of a connecting linker2016

    • Author(s)
      KO Lee, EH Kim, G Kim, JY Jung, S Katayama, S Nakamura, JY Suh
    • Journal Title

      Protein Science

      Volume: 25 Issue: 10 Pages: 1803-1811

    • DOI

      10.1002/pro.2988

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intestinal immunomodulatory effects of a hypoallergenic buckwheat Fag e 1 prepared by Maillard-type glycation with a mannan type-polysaccharide2016

    • Author(s)
      S Katayama, S Tazawa, M Kassai, T Mitani, S Nakamura
    • Journal Title

      Japanese Journal of Food Chemistry and Safety

      Volume: 23 Pages: 72-79

    • NAID

      130005262982

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced antiamyloidal activity of hydroxy cinnamic acids by enzymatic esterification with alkyl alcohols2014

    • Author(s)
      Hazuki Kondo, Haruka Sugiyama, Shigeru Katayama, Soichiro Nakamura
    • Journal Title

      Biotechnology and Applied Biochemistry

      Volume: 未定 Issue: 4 Pages: 401-407

    • DOI

      10.1002/bab.1182

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Evaluation of antioxidant and cytoprotective activities of immature fruit extracts obtained by solvent-free extraction methods2017

    • Author(s)
      MY Heng, S Katayama, T Mitani, ES Ong, S Nakamura
    • Organizer
      日本農芸化学会2017 年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Agaro-oligosaccharide enhances tight junction of Caco-2 intestine epithelial cells2017

    • Author(s)
      J Bai, N Ichikawa, K Karasawa, I Shirai, T Sakai, T Mitani, S Katayama, S Nakamura
    • Organizer
      日本農芸化学会2017 年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異なるモデル動物におけるエステル化フェルラ酸およびカフェ酸の抗老化作用2017

    • Author(s)
      丹治典子,宮崎穂菜実,橋友理香,三谷塁一,米倉真一,片山茂,中村宗一郎
    • Organizer
      日本農芸化学会2017 年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 初代培養アストロサイトにおける味噌抽出物のBDNF産生促進効果2017

    • Author(s)
      有村美紗,三谷塁一,片山茂,中村宗一郎
    • Organizer
      日本農芸化学会2017 年度大会
    • Place of Presentation
      京都女子大学(京都府京都市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effects of soy peptides on cognitive performance in senescence-accelerated mice and elderly people2016

    • Author(s)
      S Katayama, A Shimizu, T Mitani, M Maebuchi, S Nakamura
    • Organizer
      ISNFF2016
    • Place of Presentation
      米国フロリダ州
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soybean-derived basic peptides enhance production of neurotrophic factor in primary cultured astrocytes2016

    • Author(s)
      A Shimizu, T Mitani, S Nakamura, S Katayama
    • Organizer
      ISNFF2016
    • Place of Presentation
      米国フロリダ州
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Amazake-derived peptides reduce H2O2-induced oxidative stress through the upregulation of the neuroprotective genes in SK-N-SH cells2016

    • Author(s)
      HM Corpuz, T Mitani, S Katayama, S Nakamura
    • Organizer
      ISNFF2016
    • Place of Presentation
      米国フロリダ州
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical profiling of whole Huanglian extract prepared by green technology using pressurized hot-water extraction system2016

    • Author(s)
      MY Heng, ES Ong, T Mitani, S Katayama, S Nakamura
    • Organizer
      日本食品化学学会第22 回総会・学術大会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2016-06-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Modulation of neuroprotective genes by Japanese Amasake-derived bioactive peptides2016

    • Author(s)
      HM Corpuz, T Mitani, S Katayama, S Nakamura
    • Organizer
      第70 回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学(兵庫県西宮市)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] フェルラ酸エステルのHsp70発現誘導を介する神経細胞保護効果2016

    • Author(s)
      丹治典子,片山茂,三谷塁一,真壁秀文,中村宗一郎
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Modulation of neuroprotective genes by natural dietary bioactive compounds in senescence-accelerated mice2015

    • Author(s)
      Shigeru Katayama, Soichiro Nakamura
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Emerging green technologies for the chemical standardization of botanicals and herbal preparations2015

    • Author(s)
      Heng Ming Yuan, Ong Eng Shi, Shigeru Katayama, Soichiro Nakamura
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Esterification can lead to an improvement of anti-amyloidal effects and neuroprotective effects of cinnamic acid derivatives2014

    • Author(s)
      Noriko Tanji, Shigeru Katayama, Hazuki Kondo, Soichiro Nakamura
    • Organizer
      ICAAI2014
    • Place of Presentation
      Cheng Rai, Thailand
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 種々のアミロイドジェニックペプチド及びタンパク質を用いた抗アミロイド性フェノール化合物の分子デザイン2014

    • Author(s)
      中村宗一郎,片山茂,福本高大,山内陸,中林昌基,徳楽清孝
    • Organizer
      日本食品化学学会第20回総会・学術大会
    • Place of Presentation
      東京ビッグサイト,東京
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 無細胞タンパク質発現系によるAPO-IIの完全長合成と量子ドットナノプローブ法への応用に関する研究2014

    • Author(s)
      中林昌基,片山茂,福本高大,徳楽清孝,中村宗一郎
    • Organizer
      日本食品化学学会第20回総会・学術大会
    • Place of Presentation
      東京ビッグサイト,東京
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 脂肪鎖導入によるフェノール性化合物の高機能化に関する研究2014

    • Author(s)
      丹治典子,片山茂,中村宗一郎
    • Organizer
      日本食品化学学会第20回総会・学術大会
    • Place of Presentation
      東京ビッグサイト,東京
    • Year and Date
      2014-05-21 – 2014-05-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Anti-amyloidogenicities of catechol lignans converted fromsesamin and sesaminol under subcritical water condition2014

    • Author(s)
      Soichiro Nakamura, Shigeru Katayama
    • Organizer
      The 105th Annual Meeting & Expo
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2014-05-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 腸管保護剤及び腸管保護方法、医薬品、飲食品並びにタイトジャンクション関連因子発現促進剤2017

    • Inventor(s)
      唐澤幸司,白井郁也,酒井武彦,三谷塁一,片山茂,中村宗一郎
    • Industrial Property Rights Holder
      信州大学、伊那食品工業㈱
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-044560
    • Filing Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] アミロイド凝集性評価用汎用性量子ドットナノプローブ2015

    • Inventor(s)
      中村宗一郎,片山茂
    • Industrial Property Rights Holder
      国立大学法人信州大学、上野製薬(株)
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-126857
    • Filing Date
      2015-06-26
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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