Free-radical scavenging reaction of gamma-tocopherol during the decomposition of lipid hydroperoxides
| Project/Area Number |
26450155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Gifu University |
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Principal Investigator |
Yamauchi Ryo 岐阜大学, 応用生物科学部, 教授 (50126760)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | γ-トコフェロール / ビタミンＥ / 脂質過酸化 / 脂質ヒドロペルオキシド / フリーラジカル / ミセル / リポソーム / 脂質過酸化二次反応 / 抗酸化 / ミセル溶液 / 酸化二次反応 |
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| Outline of Final Research Achievements |
γ-Tocopherol (γ-TH) was reacted with free radicals from the iron- or heme-catalyzed decomposition of lipid hydroperoxides. The iron-catalyzed reaction between γ-TH and methyl linoleate hydroperoxides (MeL-OOH) in toluene gave adducts of γ-TH with peroxyl radicals originated from MeL-OOH derived alkoxyl and peroxyl radicals in addition to tocored and γ-TH dimers. The formed γ-TH dimers also trapped the MeL-OOH derived peroxyl radicals. Next, the effect of γ-TH on the hemin- or myoglobin-catalyzed decomposition of 1-palmitoyl-2-linoleoyl-3-sn-phosphatidylcholine hydroperoxide (PLPC-OOH) in micelles and liposomes was studied. The reaction products were characterized to be adducts of γ-TH with PLPC-OOH derived peroxyl and alkyl radicals. γ-TH suppressed the formation of secondary aldehydic products during the decomposition of PLPC-OOH. The results indicated that γ-TH might suppress the formation of aldehydes by trapping the PLPC-OOH derived free radicals.
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Report
(4 results)
Research Products
(2 results)
