Mechanisms underlying physiological functions of phytochemicals via proteo-hormesis
| Project/Area Number |
26450156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Hyogo (2015-2016)
Kyoto University (2014) |
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Principal Investigator |
Murakami Akira 兵庫県立大学, 環境人間学部, 教授 (10271412)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ファイトケミカル / 作用機構 / 抗炎症作用 / 適応応答 / ゼルンボン / クルクミン / ホルミシス / ストレス / 熱ショックタンパク質 / タンパク質品質管理機構 / 炎症 / 作用メカニズム / 線虫 / zerumbone / inflammation / molecular target / macrophage / HSF1 / proteo-stress / phytochemical / food factor / タンパク質ストレス / プロテオホルミシス |
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| Outline of Final Research Achievements |
Phytochemical, including polyphenols, have been shown to exhibit various physiological functions. For instance, there is ample evidence that phytochemicals have anti-obesity and anti-cancer effects in cellular and rodent models while the mechanisms underlying those functions are still unclear. In this study, a novel and unique mechanism has been found, i.e., several phytochemicals may exhibit proteo-stress properties towards cellular proteins, which may activate protein quality control systems and thereby showing anti-inflammatory functions in a cellular model.
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Report
(4 results)
Research Products
(27 results)
