| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We screened autophagy activating effect of food-derived anti-angiogenic compounds and found that carnosic acid (CA) in rosemary has the effect. To evaluate the anti-aging effect of CA, CA was orally administrated to senescence-accelerated mice prone 8 (SAMP8) for a year. CA group of SAMP8 showed a lower death rate compare to control group. In histological analyses, liver and kidney of CA group were better than those of control group. In behavior tests, CA group showed better results than control group suggesting CA prevented brain function. We found that the molecular mechanism by which CA exerts anti-aging effect is attribute to activation of FoxO3a, a transcription factor relating longevity.
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