Preventive effect of food-derived bioactive compounds with anti-angiogenic and autophagy activities on aging.
Project/Area Number |
26450159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Hiroshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
味八木 茂 広島大学, 病院(医), 講師 (10392490)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 抗老化 / 血管新生 / オートファジー / FoxO3a / 運動器 / 脳機能 / 老齢疾患 / 食品機能成分 / 脳 / 膝関節 / カルノシン酸 / 肝臓 / スルフォラファン |
Outline of Final Research Achievements |
We screened autophagy activating effect of food-derived anti-angiogenic compounds and found that carnosic acid (CA) in rosemary has the effect. To evaluate the anti-aging effect of CA, CA was orally administrated to senescence-accelerated mice prone 8 (SAMP8) for a year. CA group of SAMP8 showed a lower death rate compare to control group. In histological analyses, liver and kidney of CA group were better than those of control group. In behavior tests, CA group showed better results than control group suggesting CA prevented brain function. We found that the molecular mechanism by which CA exerts anti-aging effect is attribute to activation of FoxO3a, a transcription factor relating longevity.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Comparison of biological activities between carnosic acid and piciferic acid.2017
Author(s)
Shibata, S., Kayashima, T.,Ishitobi, H., Miyaki, S., Kawaoka, T., Matsubara, K.
Organizer
FFC’s 21st International Conference and Expo on Functional Foods
Place of Presentation
San Diego, CA, USA
Year and Date
2017-03-25
Related Report
Int'l Joint Research
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