| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Based on time-resolved emission (or absorption) measuring technique in near-infrared region, we have developed a highly-efficient method for evaluating antioxidant activities that can be applied to a wide range of targets such as food, beverages, and industrial products. By introducing the fiber-spot detection technique and a multichannel photon-counting method, we established a technology to determine the singlet-oxygen quenching rate constants accurately in short accumulation time (30 - 60 sec) with a small amount of sample in a capillary having 1 mm inner-diameter. In addition, we tried to develop some molecular probes detecting reactive-oxygen species (ROS). The probes having no fluorescence can be converted to near-infrared luminescent molecules by antioxidant reactions with ROS. We were able to obtain two types of probes, but each has drawbacks in the synthesis yield and reactivity with ROS. Further studies are needed to achieve the practical application.
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