| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Vitamin C (VC) is transported and accumulated into human cells and plays various physiological roles, but the relationship between the intracellular vitamin C transport/accumulation activity and cellular senescence has not been fully understood yet. In this study, we demonstrated that both VC transport/accumulation activity and the expression of VC-transporter were increased in old cells compared with young cells, and VC was effective in decreasing intracellular oxidative stress especially in senescent cells. Furthermore, we also found the possibility that resveratrol was involved in the regulation VC transport/accumulation activity. From these results, we show the importance of VC supplementation in senescent cells, and identified the new regulating factor for the VC transport/accumulation.
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