Chemical research on utilization of antioxidants from Jatropha curcas
| Project/Area Number |
26450231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Wood science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片山 健至 香川大学, 農学部, 教授 (00152687)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | ヤトロファ / 南洋アブラギリ / カテコール / リグナン・ネオリグナン / 生理活性 / バイオディーゼル / ジャトロファ / 抗酸化活性 / 抽出成分 / リグナン / ネオリグナン / 抗ガン活性 |
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| Outline of Final Research Achievements |
The ethyl acetate soluble fraction of the methanol extract obtained from the defatted seed residue of Jatropha curcas had the same potent antioxidant activities as Trolox. From the antioxidant fraction a catechol-type furofuran lignan, (+)-3,3’-bisdemethylpinoresinol; five catechol-type 1,4-benzodioxane neolignans, (-)-isoamericanol A, (+)-americanol A, 9’-O-methylisoamericanol A, 9’-O-methylamericanol A, and isoamericanin A; and two catechol-type sesquineolignans with furofuran and 1,4-benzodioxane moieties, isoprincepin and princepin were isolated and identified. Potent antioxidant activities of these eight compounds were also confirmed. The ethyl acetate soluble fraction of the methanol extract was found to be more effective than α-tocopherol by the tests for preventing oxidation of commercial salad oil and Jatropha oil and the biodiesel fuels (BDF) derived from the two oils.
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Report
(4 results)
Research Products
(10 results)
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[Presentation] Isoamericanol A from Jatropha curcas seed extract shows anti-cancer activity on human breast cancer cell MCF-7 by induction of G2/M stage cell cycle arrest with prolonged treatment and disruption of regular spindle formation with short-term treatment2016
Author(s)
Katagi, A., Sui, L., Kamitori, K., Suzuki, T., Katayama, T., Hossain, A., Noguchi, C., Dong, Y., Yamaguchi, F., Tokuda, M.
Organizer
第61回リグニン討論会
Place of Presentation
京都大学
Year and Date
2016-10-27
Related Report
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