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Chemical research on utilization of antioxidants from Jatropha curcas

Research Project

Project/Area Number 26450231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Wood science
Research InstitutionKagawa University

Principal Investigator

Suzuki Toshisada  香川大学, 農学部, 准教授 (80346634)

Co-Investigator(Kenkyū-buntansha) 片山 健至  香川大学, 農学部, 教授 (00152687)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsヤトロファ / 南洋アブラギリ / カテコール / リグナン・ネオリグナン / 生理活性 / バイオディーゼル / ジャトロファ / 抗酸化活性 / 抽出成分 / リグナン / ネオリグナン / 抗ガン活性
Outline of Final Research Achievements

The ethyl acetate soluble fraction of the methanol extract obtained from the defatted seed residue of Jatropha curcas had the same potent antioxidant activities as Trolox. From the antioxidant fraction a catechol-type furofuran lignan, (+)-3,3’-bisdemethylpinoresinol; five catechol-type 1,4-benzodioxane neolignans, (-)-isoamericanol A, (+)-americanol A, 9’-O-methylisoamericanol A, 9’-O-methylamericanol A, and isoamericanin A; and two catechol-type sesquineolignans with furofuran and 1,4-benzodioxane moieties, isoprincepin and princepin were isolated and identified. Potent antioxidant activities of these eight compounds were also confirmed. The ethyl acetate soluble fraction of the methanol extract was found to be more effective than α-tocopherol by the tests for preventing oxidation of commercial salad oil and Jatropha oil and the biodiesel fuels (BDF) derived from the two oils.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Antioxidative catechol lignans/neolignans isolated from defatted kernel of Jatropha curcas2016

    • Author(s)
      Toshisada Suzuki, Kyoko Eto, Yasuki Kubota, Takeshi Katayama, Tanachai Pankasemsuk
    • Journal Title

      Journal of Wood Science

      Volume: 62 Issue: 4 Pages: 339-348

    • DOI

      10.1007/s10086-016-1563-6

    • NAID

      40020903042

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibitory effect of isoamericanol A from Jatropha curcas seeds on the growth of MCF-7 human breast cancer cell line by G2/M cell cycle arrest2016

    • Author(s)
      Ayako Katagi, Li Sui, Kazuyo Kamitori, Toshisada Suzuki, Takeshi Katayama, Akram Hossain, Chisato Noguchi, Youyi Dong, Fuminori Yamaguchi, Masaaki Tokuda
    • Journal Title

      Heliyon

      Volume: 2 Issue: 1 Pages: e00055-e00055

    • DOI

      10.1016/j.heliyon.2015.e00055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] バイオディーゼル燃料用植物ジャトロファに含まれる抗酸化成分2015

    • Author(s)
      片山健至、鈴木利貞
    • Journal Title

      化学工業

      Volume: 66 Pages: 13-18

    • Related Report
      2014 Research-status Report
  • [Journal Article] Antidiabetic and Antioxidant Activity of 70% Ethanolic Extract of Graptophyllum pictum Leaves Improves Glucose Resistance in Rats2014

    • Author(s)
      Dimas Andrianto, Warus Nurcholis, Takeshi Katayama, Toshisada Suzuki
    • Journal Title

      Journal of the Forest Biomass Utilization Society

      Volume: 9 Pages: 31-36

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] イソアメリカノールAのMCF-7ヒト乳癌細胞に対する細胞増殖抑制効果のメカニズムはG2/M期アレストによる2017

    • Author(s)
      片木絢子,隋麗,神鳥和代,鈴木利貞,片山健至,アクラムホセイン,野口知里,董 有毅,山口文徳,徳田雅明
    • Organizer
      第67回日本木材学会大会
    • Place of Presentation
      九州大学
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Isoamericanol A from Jatropha curcas seed extract shows anti-cancer activity on human breast cancer cell MCF-7 by induction of G2/M stage cell cycle arrest with prolonged treatment and disruption of regular spindle formation with short-term treatment2016

    • Author(s)
      Katagi, A., Sui, L., Kamitori, K., Suzuki, T., Katayama, T., Hossain, A., Noguchi, C., Dong, Y., Yamaguchi, F., Tokuda, M.
    • Organizer
      第61回リグニン討論会
    • Place of Presentation
      京都大学
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ジャトロファの種からの抽出物であるイソアメリカノールAはMCF-7ヒト乳癌細胞をG2/M期で停止することで増殖抑制作用を示す2015

    • Author(s)
      片木絢子, 隋麗, 神鳥和代, 鈴木利貞, 片山健至, アクラム・ホセイン, 野口知里, 董有毅, 山口文徳, 徳田雅明
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Catechol-type lignan/neolignans isolated as antioxidants from the defatted seed residue of Jatropha curcas,2015

    • Author(s)
      Toshisada Suzuki, Takeshi Katayama, Tanachai Pankasemsuk
    • Organizer
      International Symposium on Wood Science and Technology 2015
    • Place of Presentation
      Tower Hall Funabori
    • Year and Date
      2015-03-15 – 2015-03-17
    • Related Report
      2014 Research-status Report
  • [Presentation] Catechol-type Lignan/Neolignans Isolated as Antioxidants from the Defatted Seed Residue of Jatropha curcas, a Shrub for Biodiesel Fuel Production2014

    • Author(s)
      Takeshi Katayama, Toshisada Suzuki, Tanachai Pankasemsuk
    • Organizer
      Polyphenols communications 2014
    • Place of Presentation
      Nagoya University
    • Year and Date
      2014-09-02 – 2014-09-06
    • Related Report
      2014 Research-status Report
  • [Presentation] バイオディーゼル燃料用植物ジャトロファ由来のバイオマスの有効利用、抗酸化成分等の生物活性成分の探索2014

    • Author(s)
      片山健至、鈴木利貞
    • Organizer
      第81回紙パルプ研究発表会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-06-02 – 2014-06-03
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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