Antibacterial activity of various nanoparticles against main fish disease bacteria causal severe damage.

• Project/Area Number: 26450262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Aquatic bioproduction science
• Research Institution: Kochi University
• Principal Investigator: Oshima Syunichirou 高知大学, 教育研究部総合科学系黒潮圏科学部門, 教授 (80325406)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 魚病 / 細菌 / 増殖抑制 / 感染防御 / ナノ粒子 / 魚病細菌 / 高分子抗菌構造体 / 抗菌活性

Outline of Final Research Achievements

Antibacterial activity of various nanoparticles against main fish disease bacteria were investigated using in vitro(plate methods) and in vivo(experimental infections) system.　These nanoparticles showed enough level of antibacterial activity against Photobacterium damselae subsp. piscicida, Lactococcus garvieae, Streptococcus iniae and Vibrio alginolyticus, respectively.And, challenge tests were done by the immersion infection method using Streptococcus iniae after various administrations of
nanoparticle for a fixed period of time. The results show the effectiveness of various administrations of nanoparticles against Streptococcus iniae in rainbow trout.