| Project/Area Number |
26450281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
白川 仁 東北大学, 農学研究科, 准教授 (40206280)
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| Research Collaborator |
DEVLIN R. H. カナダ水産海洋省国立ウエストバンクーバー研究所, 遺伝子工学部門, 部長
SOGA TOMOYOSHI 慶應義塾大学, 先端生命科学研究所, 教授
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 農林水産物 / 水産学 / 栄養学 / 組換え食品 / バイオテクノロジー / 生理学 / 国際情報交流（カナダ） |
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| Outline of Final Research Achievements |
Growth in fish is regulated by the growth hormone (GH)-insulin-like growth factor (IGF)-I axis. Little is known concerning the in vivo levels of metabolites, energy production and the mechanism of enhancement of growth in GH transgenic fish. The present study examined the features of GH transgenic coho salmon (Oncorhynchus kisutch) by metabolomic and mitochondrial function analysis. The difference found between transgenic (T) and non-transgenic (NT) fish was that glycolysis metabolite levels changed in the muscle of transgenic fish. The feature of metabolites in T fish which were fully fed after ration-restriction was not similar to that in fully-fed T fish. Mitochondrial function in the muscle of T fish was found to be promoted by GH transgenesis. The results suggest that GH transgenesis can improve the metabolic pathway and mitochondrial function associated with rapid growth.
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