A study on the mechanisms of energy production in super salmon and its appl ication for cultured fish
Project/Area Number |
26450281
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Aquatic life science
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
白川 仁 東北大学, 農学研究科, 准教授 (40206280)
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Research Collaborator |
DEVLIN R. H. カナダ水産海洋省国立ウエストバンクーバー研究所, 遺伝子工学部門, 部長
SOGA TOMOYOSHI 慶應義塾大学, 先端生命科学研究所, 教授
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 農林水産物 / 水産学 / 栄養学 / 組換え食品 / バイオテクノロジー / 生理学 / 国際情報交流(カナダ) |
Outline of Final Research Achievements |
Growth in fish is regulated by the growth hormone (GH)-insulin-like growth factor (IGF)-I axis. Little is known concerning the in vivo levels of metabolites, energy production and the mechanism of enhancement of growth in GH transgenic fish. The present study examined the features of GH transgenic coho salmon (Oncorhynchus kisutch) by metabolomic and mitochondrial function analysis. The difference found between transgenic (T) and non-transgenic (NT) fish was that glycolysis metabolite levels changed in the muscle of transgenic fish. The feature of metabolites in T fish which were fully fed after ration-restriction was not similar to that in fully-fed T fish. Mitochondrial function in the muscle of T fish was found to be promoted by GH transgenesis. The results suggest that GH transgenesis can improve the metabolic pathway and mitochondrial function associated with rapid growth.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Effect of thermal stressors on growth-related gene expressions in cultured fish2015
Author(s)
Nakano, T., Kameda, M., Yamaguchi, T., Sato, M., Afonso, L.O.B., Iwama, G.K., Devlin, R.H.
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Journal Title
Marine Productivity: Perturbations and Resilience of Socio-ecosystems (Ceccaldi, H.J. et al. (eds.)), Springer International Publishing
Volume: -
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effect of severe environmental thermal stress on redox state in salmon2014
Author(s)
Nakano, T., Kameda, M., Shoji, Y., Hayashi, S., Yamaguchi, T., Sato, M.
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Journal Title
Redox Biol. (Official J. Soc. Free Radic. Biol. Med. and Soc. Free Radic. Res.-Eur.)
Volume: 2
Pages: 772-776
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Effect of excessive doses of oxytetracycline on antioxidative capacity in coho salmon2014
Author(s)
Nakano, T., Hayashi, S., Nagamine, N., Yamaguchi, T., Sato, M.
Organizer
International Conference of Asian Environmental Chemistry 2014 (ICAEC2014)
Place of Presentation
Convention Center, Chulabhorn Research Institute, Bangkok, Thailand
Year and Date
2014-11-24 – 2014-11-26
Related Report
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[Presentation] Effects of fasting on metabolome profiling in growth hormone transgenic fish2014
Author(s)
Nakano, T., Shirakawa, H., Yamaguchi, T., Sato, Yeo, G., Devlin, R.H., Soga, T.
Organizer
The 87th Annual Meeting of the Japanese Biochemical Society
Place of Presentation
Kyoto International Conference Center
Year and Date
2014-10-15 – 2014-10-18
Related Report
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[Presentation] Fish stress become visible: a new attempt to use glucose biosensor for real-time monitoring fish stress2014
Author(s)
Wu, H., Aoki, A., Suzuki, T., Otsuka, J., Hibi, K., Arimoto, T., Nakano, T., Ren, H., Endo, H.
Organizer
24th Anniversary World Congress on Biosensors (Biosensors 2014)
Place of Presentation
Melbourne Convention Center, Melbourne, Australia
Year and Date
2014-05-27 – 2014-05-30
Related Report